Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Cathepsin B precursor | 0.00885615 | 0.142259 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00270192 | 0.0172854 | 0.0459215 |
Loa Loa (eye worm) | calpain family protein 1 | 0.00338497 | 0.0311559 | 0.0827709 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.00885615 | 0.142259 | 0.5 |
Brugia malayi | calpain family protein 1 | 0.00338497 | 0.0311559 | 0.038623 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.00345881 | 0.0326555 | 0.0427989 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0203868 | 0.376411 | 1 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0510951 | 1 | 1 |
Brugia malayi | calpain family protein 1 | 0.00338497 | 0.0311559 | 0.038623 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0510951 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.0203868 | 0.376411 | 0.365442 |
Echinococcus multilocularis | calpain A | 0.00345881 | 0.0326555 | 0.0205108 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.00885615 | 0.142259 | 0.347993 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0203868 | 0.376411 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0203868 | 0.376411 | 1 |
Echinococcus granulosus | cathepsin b | 0.0203868 | 0.376411 | 0.365442 |
Echinococcus multilocularis | organic anion transporting polypeptide 30B | 0.00270192 | 0.0172854 | 0.0049477 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0203868 | 0.376411 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00270192 | 0.0172854 | 0.0459215 |
Onchocerca volvulus | 0.00270192 | 0.0172854 | 1 | |
Echinococcus multilocularis | cathepsin b | 0.0203868 | 0.376411 | 0.368582 |
Echinococcus granulosus | calpain A | 0.00345881 | 0.0326555 | 0.0156405 |
Loa Loa (eye worm) | hypothetical protein | 0.00270192 | 0.0172854 | 0.0459215 |
Onchocerca volvulus | 0.00270192 | 0.0172854 | 1 | |
Onchocerca volvulus | 0.00270192 | 0.0172854 | 1 | |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.00885615 | 0.142259 | 0.5 |
Echinococcus multilocularis | cathepsin b | 0.0203868 | 0.376411 | 0.368582 |
Onchocerca volvulus | Putative organic anion transporter | 0.00270192 | 0.0172854 | 1 |
Echinococcus multilocularis | family C2 unassigned peptidase (C02 family) | 0.00345881 | 0.0326555 | 0.0205108 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0203868 | 0.376411 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00270192 | 0.0172854 | 0.0459215 |
Onchocerca volvulus | Putative organic anion transporter | 0.00270192 | 0.0172854 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00270192 | 0.0172854 | 0.0459215 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.00885615 | 0.142259 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.00885615 | 0.142259 | 0.5 |
Onchocerca volvulus | 0.00270192 | 0.0172854 | 1 | |
Loa Loa (eye worm) | sodium-independent organic anion transporter | 0.00270192 | 0.0172854 | 0.0459215 |
Toxoplasma gondii | cathepsin B | 0.00885615 | 0.142259 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.00885615 | 0.142259 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00270192 | 0.0172854 | 0.0459215 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.00885615 | 0.142259 | 0.347993 |
Echinococcus multilocularis | Solute carrier organic anion transporter family | 0.00270192 | 0.0172854 | 0.0049477 |
Loa Loa (eye worm) | hypothetical protein | 0.00338497 | 0.0311559 | 0.0827709 |
Loa Loa (eye worm) | cathepsin B | 0.00885615 | 0.142259 | 0.377934 |
Loa Loa (eye worm) | calpain family protein 1 | 0.00246129 | 0.012399 | 0.0329401 |
Echinococcus granulosus | family C2 unassigned peptidase C02 family | 0.00345881 | 0.0326555 | 0.0156405 |
Loa Loa (eye worm) | hypothetical protein | 0.00277438 | 0.0187569 | 0.0498308 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.00338497 | 0.0311559 | 0.038623 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0203868 | 0.376411 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00270192 | 0.0172854 | 0.0459215 |
Onchocerca volvulus | Putative organic anion transporter | 0.00270192 | 0.0172854 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00246129 | 0.012399 | 0.0329401 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.00345881 | 0.0326555 | 0.0427989 |
Onchocerca volvulus | 0.00270192 | 0.0172854 | 1 | |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0203868 | 0.376411 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.83 uM | Antiplasmodial activity against chloroquine-resistant blood-stage Plasmodium falciparum W2 after 48 hrs by flow cytometric analysis | ChEMBL. | 22683112 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 22683112 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.