Detailed information for compound 1653973

Basic information

Technical information
  • TDR Targets ID: 1653973
  • Name: (2Z,4E)-5-(4-dimethylaminophenyl)-2-phenylpen ta-2,4-dienenitrile
  • MW: 274.36 | Formula: C19H18N2
  • H donors: 0 H acceptors: 1 LogP: 4.47 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#C/C(=C\C=C\c1ccc(cc1)N(C)C)/c1ccccc1
  • InChi: 1S/C19H18N2/c1-21(2)19-13-11-16(12-14-19)7-6-10-18(15-20)17-8-4-3-5-9-17/h3-14H,1-2H3/b7-6+,18-10+
  • InChiKey: PZOBYPZHMFNXCV-ZOQHSEBNSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-(4-dimethylaminophenyl)-2-phenylpenta-2,4-dienenitrile
  • 5-(4-dimethylaminophenyl)-2-phenyl-penta-2,4-dienenitrile
  • (2Z,4E)-5-(4-dimethylaminophenyl)-2-phenyl-penta-2,4-dienenitrile
  • 5-(4-(Dimethylamino)phenyl)-2-phenyl-2,4-pentadienenitrile
  • AIDS-144500
  • AIDS144500
  • NSC667252
  • NCI60_023411
  • 2,4-Pentadienenitrile, 5-[4-(dimethylamino)phenyl]- 2-phenyl-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0107 0.2114 0.7081
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0412 0.1313
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0225 0.3046
Toxoplasma gondii transitional endoplasmic reticulum ATPase, putative 0.0035 0.0486 0.0707
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0533 0.546
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.0025 0.5
Trypanosoma brucei glucose transporter, putative 0.0033 0.0437 0.4427
Echinococcus multilocularis 0.0045 0.0702 0.2295
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0033 0.0427 0.1365
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0024 0.0238 0.0722
Plasmodium falciparum protein kinase 7 0.0301 0.6551 0.6542
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.0533 0.0779
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.2114 0.7081
Leishmania major protein kinase, putative 0.0033 0.0427 0.4324
Brugia malayi valosin containing protein 0.0035 0.047 0.1509
Loa Loa (eye worm) hypothetical protein 0.0035 0.047 0.1509
Schistosoma mansoni tyrosine kinase 0.0077 0.1433 0.4774
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0412 0.195
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0412 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0275 0.085
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0427 0.1365
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0225 0.0681
Echinococcus multilocularis calcium dependent protein kinase 0.0031 0.0381 0.1208
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.2114 0.7081
Schistosoma mansoni tyrosine kinase 0.0144 0.2975 1
Plasmodium vivax hexose transporter 0.0107 0.2114 0.2094
Echinococcus granulosus epidermal growth factor receptor 0.0144 0.2975 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0533 0.546
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0059 0.1025 0.339
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0095 0.0755
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Schistosoma mansoni tyrosine kinase 0.0077 0.1433 0.4774
Mycobacterium ulcerans ATPase 0.0035 0.0486 1
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0172 0.3611 0.3595
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Echinococcus granulosus General substrate transporter 0.0092 0.1772 0.5923
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0437 0.2066
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Leishmania major Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog 0.0056 0.0956 1
Brugia malayi Furin-like cysteine rich region family protein 0.0144 0.2975 1
Toxoplasma gondii protein kinase, putative 0.0301 0.6551 1
Plasmodium vivax cell division cycle protein 48 homologue, putative 0.0056 0.0956 0.0933
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Echinococcus granulosus insulin receptor 0.0046 0.0735 0.2407
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0412 0.8401
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0107 0.2114 0.7081
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0533 0.546
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0033 0.0428 0.0617
Toxoplasma gondii facilitative glucose transporter GT1 0.0107 0.2114 0.3201
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Trypanosoma brucei glucose transporter, putative 0.0033 0.0437 0.4427
Echinococcus granulosus calcium dependent protein kinase 0.0031 0.0381 0.1208
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Schistosoma mansoni tyrosine kinase 0.0078 0.1452 0.4837
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0437 0.4427
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Plasmodium falciparum calcium-dependent protein kinase 4 0.0033 0.0428 0.0404
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0437 0.2066
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0025 0.0116
Echinococcus multilocularis epidermal growth factor receptor 0.0078 0.1452 0.4837
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0412 0.1313
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0144 0.258
Echinococcus granulosus epidermal growth factor receptor 0.0078 0.1452 0.4837
Loa Loa (eye worm) sugar transporter 0.0107 0.2114 0.7081
Loa Loa (eye worm) VCP protein 0.0024 0.0238 0.0722
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0533 0.546
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0437 0.4427
Leishmania major glucose transporter, lmgt3 0.0033 0.0437 0.4427
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.0225 0.0681
Schistosoma mansoni tyrosine kinase 0.0046 0.0735 0.2407
Leishmania major glucose transporter, lmgt1 0.0033 0.0437 0.4427
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0078 0.1452 0.4837
Loa Loa (eye worm) hypothetical protein 0.0033 0.0427 0.1365
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0437 0.2066
Schistosoma mansoni tyrosine kinase 0.0077 0.1433 0.4774
Trypanosoma brucei glucose transporter 2A 0.0033 0.0437 0.4427
Plasmodium falciparum calcium-dependent protein kinase 3 0.0033 0.0428 0.0404
Toxoplasma gondii cell division protein CDC48AP 0.0035 0.0486 0.0707
Brugia malayi Cam kinase protein 1 0.0033 0.0427 0.1365
Echinococcus multilocularis General substrate transporter 0.0092 0.1772 0.5923
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0033 0.0428 0.0404
Plasmodium falciparum proline--tRNA ligase 0.0037 0.0533 0.051
Trypanosoma brucei glucose transporter, putative 0.0033 0.0437 0.4427
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.0225 0.2157
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Giardia lamblia AAA family ATPase 0.0035 0.0486 1
Toxoplasma gondii cell division protein CDC48CY 0.0059 0.1025 0.1532
Brugia malayi Sugar transporter family protein 0.0107 0.2114 0.7081
Echinococcus multilocularis epidermal growth factor receptor 0.0144 0.2975 1
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0033 0.0427 0.1365
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0412 0.1313
Schistosoma mansoni glucose transport protein 0.0107 0.2114 0.7081
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.2114 0.7081
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0172 0.3611 0.5495
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Entamoeba histolytica protein kinase, putative 0.0033 0.0427 0.2763
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0056 0.0956 0.3156
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0059 0.1025 0.339
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0427 0.1365
Trypanosoma brucei Valosin-containing protein 0.0056 0.0956 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0225 0.0681
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0437 0.4427
Schistosoma mansoni protein kinase 0.0033 0.0427 0.1365
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0033 0.0428 0.0617
Brugia malayi vesicle-fusing ATPase 0.0035 0.047 0.1509
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0144 0.258
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0225 0.1066
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Plasmodium vivax cell division cycle ATPase, putative 0.0021 0.0169 0.0144
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.0225 0.0681
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0225 0.4353
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0437 0.4427
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0107 0.2114 0.7081
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0412 0.1313
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0427 0.1365
Leishmania major glucose transporter, lmgt2 0.0033 0.0437 0.4427
Plasmodium falciparum calcium-dependent protein kinase 5 0.0033 0.0428 0.0404
Echinococcus granulosus transitional endoplasmic reticulum atpase 0.0059 0.1025 0.339
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0046 0.0735 0.2407
Schistosoma mansoni glucose transport protein 0.0107 0.2114 0.7081
Trypanosoma cruzi Valosin-containing protein, putative 0.0056 0.0956 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0225 0.4353
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Mycobacterium tuberculosis Putative conserved ATPase 0.0035 0.0486 1
Brugia malayi Protein kinase domain containing protein 0.0046 0.0735 0.2407
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0427 0.1365
Brugia malayi lysyl-tRNA synthetase 0.0024 0.0225 0.0681
Loa Loa (eye worm) TK/INSR protein kinase 0.0046 0.0735 0.2407
Loa Loa (eye worm) hypothetical protein 0.0032 0.0412 0.1313
Plasmodium falciparum mitogen-activated protein kinase 2 0.0172 0.3611 0.3595
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Loa Loa (eye worm) hypothetical protein 0.0024 0.0225 0.0681
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0024 0.0238 0.0722
Trypanosoma brucei glucose transporter, putative 0.0033 0.0437 0.4427
Trichomonas vaginalis myo-inositol transporter, putative 0.0015 0.0025 0.0116
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.0225 0.0201
Entamoeba histolytica cdc48-like protein, putative 0.0056 0.0956 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0033 0.0427 0.4324
Trypanosoma cruzi hexose transporter 0.0033 0.0437 0.4427
Schistosoma mansoni protein kinase 0.0033 0.0427 0.1365
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0033 0.0428 0.0404
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Loa Loa (eye worm) TK/EGFR protein kinase 0.0144 0.2975 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Schistosoma mansoni tyrosine kinase 0.0078 0.1452 0.4837
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0107 0.2114 0.7081
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0046 0.0735 0.2407
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0033 0.0428 0.0617
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0025 0.0116
Onchocerca volvulus Transitional endoplasmic reticulum ATPase homolog 0.0059 0.1025 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.2114 0.7081
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Plasmodium vivax CDK-related protein kinase 6, putative 0.0453 1 1
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0033 0.0427 0.1365
Brugia malayi transitional endoplasmic reticulum ATPase TER94, putative 0.0024 0.0238 0.0722
Echinococcus multilocularis insulin receptor 0.0046 0.0735 0.2407
Schistosoma mansoni hypothetical protein 0.0107 0.2114 0.7081
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Loa Loa (eye worm) vesicle-fusing ATPase 0.0035 0.047 0.1509
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.0225 0.2157
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0437 0.2066
Trichomonas vaginalis sugar transport protein, putative 0.0015 0.0025 0.0116
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Plasmodium vivax calcium-dependent protein kinase, putative 0.0033 0.0428 0.0404
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0025 0.0116
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0412 0.2557
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0533 0.546
Loa Loa (eye worm) hypothetical protein 0.0032 0.0412 0.1313
Trichomonas vaginalis glucose transporter, putative 0.0015 0.0025 0.0116
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.0225 0.4353
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0427 0.1365
Schistosoma mansoni glucose transport protein 0.0107 0.2114 0.7081
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0437 0.4427
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0427 0.1365
Trypanosoma brucei glucose transporter, putative 0.0033 0.0437 0.4427
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.0533 0.051
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0437 0.4427
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0412 0.1313
Trichomonas vaginalis spermatogenesis associated factor, putative 0.0059 0.1025 0.4848
Schistosoma mansoni protein kinase 0.0033 0.0427 0.1365
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.0225 0.0201
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0412 0.1313
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Schistosoma mansoni tyrosine kinase 0.0046 0.0735 0.2407
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Trichomonas vaginalis CAMK family protein kinase 0.0033 0.0427 0.2021
Plasmodium falciparum cell division cycle protein 48 homologue, putative 0.0056 0.0956 0.0933
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.0225 0.0308
Entamoeba histolytica transitional endoplasmic reticulum ATPase, putative 0.0056 0.0956 1
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.2114 1
Trypanosoma brucei glucose transporter 1E 0.0033 0.0437 0.4427
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0033 0.0428 0.0404
Trypanosoma brucei glucose transporter, putative 0.0033 0.0437 0.4427
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0437 0.4427
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Plasmodium falciparum hexose transporter 0.0107 0.2114 0.2094
Plasmodium falciparum calcium-dependent protein kinase 2 0.0033 0.0428 0.0404
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0025 0.0116
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.0225 0.5
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Entamoeba histolytica protein kinase, putative 0.0033 0.0427 0.2763
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0025 0.0116
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0437 0.2066
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.0225 0.2157
Trypanosoma brucei glucose transporter, putative 0.0033 0.0437 0.4427
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0033 0.0427 0.1365
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0427 0.1365
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0427 0.1365
Trypanosoma brucei glucose transporter, putative 0.0033 0.0437 0.4427
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0437 0.2066
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0158 0.075
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0437 0.2066
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Plasmodium falciparum calcium-dependent protein kinase 1 0.0033 0.0428 0.0404

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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