Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 12 (potassium/chloride transporter), member 5 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.6128 | 0.6128 |
Trichomonas vaginalis | cation chloride cotransporter, putative | 0.0019 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0019 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0019 | 0 | 0.5 |
Brugia malayi | Amino acid permease family protein | 0.0054 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.447 | 0.447 |
Echinococcus granulosus | solute carrier family 12 | 0.0054 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.6128 | 0.6128 |
Echinococcus multilocularis | solute carrier family 12 | 0.0054 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.447 | 0.447 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0019 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.447 | 0.447 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0019 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.6128 | 0.6128 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.8341 | 0.8341 |
Trichomonas vaginalis | cation chloride cotransporter, putative | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.8341 | 0.8341 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.447 | 0.447 |
Loa Loa (eye worm) | amino acid permease | 0.0041 | 0.6128 | 0.6128 |
Schistosoma mansoni | solute carrier family 12 electroneutral k-cl cotransporter | 0.0054 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.8341 | 0.8341 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.6128 | 0.6128 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 2.9 uM | Antagonist activity at KCC2 expressed in human HEK293 cells assessed as decrease in Tl-stimulated fluorescence increase after 8 mins by fluorescence analysis | ChEMBL. | 22727639 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.