Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ketohexokinase (fructokinase) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | hypothetical protein | Get druggable targets OG5_133459 | All targets in OG5_133459 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133459 | All targets in OG5_133459 |
Onchocerca volvulus | Get druggable targets OG5_133459 | All targets in OG5_133459 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | ribokinase, putative | ketohexokinase (fructokinase) | 298 aa | 307 aa | 21.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0675 | 0.0675 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0042 | 0.0675 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0042 | 0.0675 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0042 | 0.0675 | 0.0675 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0042 | 0.0675 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0042 | 0.0675 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0042 | 0.0675 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0042 | 0.0675 | 0.0675 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0042 | 0.0675 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0042 | 0.0675 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0042 | 0.0675 | 0.0675 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0042 | 0.0675 | 0.0675 |
Brugia malayi | nuclear hormone receptor | 0.0042 | 0.0675 | 0.0675 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0042 | 0.0675 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0042 | 0.0675 | 0.0675 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0042 | 0.0675 | 0.0675 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0042 | 0.0675 | 0.0675 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0042 | 0.0675 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0042 | 0.0675 | 0.0675 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0042 | 0.0675 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0042 | 0.0675 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0042 | 0.0675 | 1 |
Brugia malayi | steroid hormone receptor | 0.0042 | 0.0675 | 0.0675 |
Onchocerca volvulus | 0.0312 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0675 | 0.0675 |
Schistosoma mansoni | thyroid hormone receptor | 0.0042 | 0.0675 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0042 | 0.0675 | 0.0675 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0042 | 0.0675 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0042 | 0.0675 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0675 | 0.0675 |
Brugia malayi | ecdysteroid receptor | 0.0042 | 0.0675 | 0.0675 |
Schistosoma mansoni | thyroid hormone receptor | 0.0042 | 0.0675 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0042 | 0.0675 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0042 | 0.0675 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0042 | 0.0675 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0042 | 0.0675 | 0.0675 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0042 | 0.0675 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0042 | 0.0675 | 0.0675 |
Echinococcus granulosus | FTZ F1 alpha | 0.0042 | 0.0675 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0675 | 0.0675 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0042 | 0.0675 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0675 | 0.0675 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0042 | 0.0675 | 0.0675 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0042 | 0.0675 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0042 | 0.0675 | 0.0675 |
Brugia malayi | nuclear receptor NHR-88 | 0.0042 | 0.0675 | 0.0675 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0675 | 0.0675 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0042 | 0.0675 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0042 | 0.0675 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0042 | 0.0675 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0042 | 0.0675 | 0.0675 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0042 | 0.0675 | 0.0675 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0042 | 0.0675 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0042 | 0.0675 | 0.0675 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0042 | 0.0675 | 0.0675 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0042 | 0.0675 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0042 | 0.0675 | 0.0675 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0042 | 0.0675 | 0.0675 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0042 | 0.0675 | 0.0675 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0042 | 0.0675 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0042 | 0.0675 | 0.0675 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0042 | 0.0675 | 0.0675 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0042 | 0.0675 | 0.0675 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0675 | 0.0675 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0042 | 0.0675 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0042 | 0.0675 | 0.0675 |
Schistosoma mansoni | coup transcription factor | 0.0042 | 0.0675 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0675 | 0.0675 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 50 nM | Inhibition of recombinant human hepatic KHKC | ChEMBL. | 22795331 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.