Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.073 | 0.4056 | 1 |
Brugia malayi | transcriptional regulator, Sir2 family protein | 0.073 | 0.4056 | 1 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.073 | 0.4056 | 0.5 |
Echinococcus multilocularis | chromatin regulatory protein sir2 | 0.073 | 0.4056 | 0.3513 |
Echinococcus granulosus | NAD dependent deacetylase sirtuin 3 | 0.073 | 0.4056 | 0.3513 |
Trypanosoma cruzi | Silent information regulator 2 related protein 1 | 0.073 | 0.4056 | 0.5 |
Loa Loa (eye worm) | transcriptional regulator | 0.073 | 0.4056 | 1 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.073 | 0.4056 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 0.0837 | 0.2065 |
Trypanosoma brucei | Silent information regulator 2 related protein 1 | 0.073 | 0.4056 | 0.5 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.073 | 0.4056 | 0.5 |
Echinococcus multilocularis | NAD dependent deacetylase sirtuin 3 | 0.073 | 0.4056 | 0.3513 |
Leishmania major | silent information regulator 2, putative | 0.073 | 0.4056 | 0.5 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.1613 | 1 | 1 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.073 | 0.4056 | 1 |
Echinococcus granulosus | chromatin regulatory protein sir2 | 0.073 | 0.4056 | 0.3513 |
Trypanosoma cruzi | Silent information regulator 2 related protein 1 | 0.073 | 0.4056 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.073 | 0.4056 | 1 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.073 | 0.4056 | 1 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.073 | 0.4056 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 60 % | Inhibition of Smo-mediated Hh signaling in human Shh-light2 cells at 0.3 uM by luciferase reporter gene assay | ChEMBL. | 22268551 |
Inhibition (functional) | = 100 % | Inhibition of Smo-mediated Hh signaling in human Shh-light2 cells at 3 uM by luciferase reporter gene assay | ChEMBL. | 22268551 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.