Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | furin (paired basic amino acid cleaving enzyme) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | DNA topoisomerase II, putative | 0.041 | 0.1985 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.0596 | 0.1814 |
Schistosoma mansoni | prokaryotic DNA topoisomerase | 0.0125 | 0.0289 | 0.1454 |
Trypanosoma brucei | DNA topoisomerase ii | 0.1014 | 0.5586 | 1 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.041 | 0.1985 | 0.3202 |
Brugia malayi | DNA topoisomerase III | 0.0125 | 0.0289 | 0.0474 |
Schistosoma mansoni | prokaryotic DNA topoisomerase | 0.0125 | 0.0289 | 0.1454 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.1754 | 1 | 1 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0285 | 0.1237 | 0.1791 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.041 | 0.1985 | 1 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.041 | 0.1985 | 1 |
Brugia malayi | GRF zinc finger family protein | 0.0125 | 0.0289 | 0.0474 |
Brugia malayi | Probable DNA topoisomerase II | 0.041 | 0.1985 | 1 |
Echinococcus multilocularis | 0.0143 | 0.0392 | 0.1164 | |
Plasmodium falciparum | DNA topoisomerase 2 | 0.041 | 0.1985 | 0.1747 |
Trichomonas vaginalis | prokaryotic DNA topoisomerase, putative | 0.0125 | 0.0289 | 0.0589 |
Leishmania major | DNA topoisomerase ii | 0.0285 | 0.1237 | 0.1791 |
Schistosoma mansoni | subfamily S8B unassigned peptidase (S08 family) | 0.0177 | 0.0596 | 0.3004 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.1754 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.1754 | 1 | 1 |
Loa Loa (eye worm) | endoprotease bli-4 | 0.0177 | 0.0596 | 0.1814 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0285 | 0.1237 | 0.1791 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.1754 | 1 | 1 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.1754 | 1 | 1 |
Plasmodium falciparum | DNA gyrase subunit B | 0.1754 | 1 | 1 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.1014 | 0.5586 | 1 |
Echinococcus granulosus | neuroendocrine convertase 2 | 0.0111 | 0.0204 | 0.0121 |
Giardia lamblia | DNA topoisomerase II | 0.0355 | 0.1657 | 1 |
Echinococcus granulosus | furin | 0.0177 | 0.0596 | 0.2296 |
Schistosoma mansoni | DNA topoisomerase II | 0.041 | 0.1985 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.1014 | 0.5586 | 1 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.041 | 0.1985 | 1 |
Echinococcus granulosus | DNA topoisomerase 3 beta 1 | 0.0125 | 0.0289 | 0.0589 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0604 | 0.3142 | 1 |
Trichomonas vaginalis | prokaryotic DNA topoisomerase, putative | 0.0125 | 0.0289 | 0.0589 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.041 | 0.1985 | 1 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.041 | 0.1985 | 0.1747 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.115 | 0.6399 | 0.6292 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.041 | 0.1985 | 1 |
Echinococcus granulosus | DNA topoisomerase 3 alpha | 0.0125 | 0.0289 | 0.0589 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.041 | 0.1985 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0285 | 0.1237 | 0.5592 |
Echinococcus multilocularis | DNA topoisomerase 3 beta 1 | 0.0125 | 0.0289 | 0.0589 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0285 | 0.1237 | 0.1791 |
Brugia malayi | DNA topoisomerase III beta-1 | 0.0125 | 0.0289 | 0.0474 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.1014 | 0.5586 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0285 | 0.1237 | 0.1791 |
Echinococcus multilocularis | rho GTPase activating protein 20 | 0.0125 | 0.0289 | 0.0589 |
Loa Loa (eye worm) | hypothetical protein | 0.0285 | 0.1237 | 0.5592 |
Brugia malayi | endoprotease bli-4 precursor | 0.0177 | 0.0596 | 0.2202 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.041 | 0.1985 | 1 |
Echinococcus multilocularis | neuroendocrine convertase 2 | 0.0111 | 0.0204 | 0.0121 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.041 | 0.1985 | 1 |
Brugia malayi | celfurPC protein | 0.0143 | 0.0392 | 0.1056 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.1014 | 0.5586 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.041 | 0.1985 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1.6 nM | Inhibition of furin | ChEMBL. | 22682919 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.