Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | furin (paired basic amino acid cleaving enzyme) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0279 | 0.1808 | 1 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0279 | 0.1808 | 1 |
Schistosoma mansoni | prokaryotic DNA topoisomerase | 0.0085 | 0.0074 | 0.0407 |
Echinococcus multilocularis | proprotein convertase subtilisin:kexin type 5 | 0.0108 | 0.0274 | 0.1157 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0279 | 0.1808 | 1 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0193 | 0.1043 | 0.1791 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0279 | 0.1808 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0782 | 0.6319 | 0.6292 |
Leishmania major | DNA topoisomerase ii | 0.0193 | 0.1043 | 0.1791 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0108 | 0.0274 | 0.1157 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1043 | 0.5592 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0689 | 0.5488 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1043 | 0.5592 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0108 | 0.0274 | 0.1157 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0279 | 0.1808 | 1 |
Echinococcus granulosus | furin | 0.0177 | 0.0897 | 0.4749 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0279 | 0.1808 | 1 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0279 | 0.1808 | 0.3202 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0689 | 0.5488 | 1 |
Brugia malayi | celfurPC protein | 0.0143 | 0.059 | 0.2978 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0689 | 0.5488 | 1 |
Echinococcus multilocularis | neuroendocrine convertase 2 | 0.0111 | 0.0307 | 0.1346 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0279 | 0.1808 | 0.1747 |
Brugia malayi | proprotein convertase 2 | 0.0111 | 0.0307 | 0.1346 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0279 | 0.1808 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.0897 | 0.4749 |
Brugia malayi | neuroendocrine convertase 1 precursor | 0.0111 | 0.0307 | 0.1346 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0193 | 0.1043 | 0.1791 |
Plasmodium falciparum | DNA gyrase subunit B | 0.1192 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.1192 | 1 | 1 |
Schistosoma mansoni | subfamily S8B unassigned peptidase (S08 family) | 0.0177 | 0.0897 | 0.4963 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0193 | 0.1043 | 0.1791 |
Schistosoma mansoni | prokaryotic DNA topoisomerase | 0.0085 | 0.0074 | 0.0407 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0279 | 0.1808 | 0.1747 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0279 | 0.1808 | 1 |
Echinococcus multilocularis | 0.0143 | 0.059 | 0.2978 | |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0279 | 0.1808 | 1 |
Echinococcus granulosus | neuroendocrine convertase 2 | 0.0111 | 0.0307 | 0.1346 |
Brugia malayi | Probable DNA topoisomerase II | 0.0279 | 0.1808 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0193 | 0.1043 | 0.1791 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.1192 | 1 | 1 |
Brugia malayi | endoprotease bli-4 precursor | 0.0177 | 0.0897 | 0.4749 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0689 | 0.5488 | 1 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.1192 | 1 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.1192 | 1 | 1 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.1192 | 1 | 0.5 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0279 | 0.1808 | 1 |
Giardia lamblia | DNA topoisomerase II | 0.0241 | 0.1472 | 1 |
Loa Loa (eye worm) | endoprotease bli-4 | 0.0177 | 0.0897 | 0.4749 |
Echinococcus granulosus | proprotein convertase subtilisin:kexin type 5 | 0.0108 | 0.0274 | 0.1157 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.041 | 0.299 | 1 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0689 | 0.5488 | 1 |
Schistosoma mansoni | DNA topoisomerase II | 0.0279 | 0.1808 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1 nM | Inhibition of furin | ChEMBL. | 22682919 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.