Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | furin (paired basic amino acid cleaving enzyme) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.041 | 0.1985 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.1014 | 0.5586 | 1 |
Brugia malayi | celfurPC protein | 0.0143 | 0.0392 | 0.1056 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.041 | 0.1985 | 1 |
Echinococcus multilocularis | neuroendocrine convertase 2 | 0.0111 | 0.0204 | 0.0121 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.041 | 0.1985 | 1 |
Brugia malayi | endoprotease bli-4 precursor | 0.0177 | 0.0596 | 0.2202 |
Loa Loa (eye worm) | hypothetical protein | 0.0285 | 0.1237 | 0.5592 |
Echinococcus multilocularis | rho GTPase activating protein 20 | 0.0125 | 0.0289 | 0.0589 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0285 | 0.1237 | 0.1791 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.1014 | 0.5586 | 1 |
Brugia malayi | DNA topoisomerase III beta-1 | 0.0125 | 0.0289 | 0.0474 |
Echinococcus multilocularis | DNA topoisomerase 3 beta 1 | 0.0125 | 0.0289 | 0.0589 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0285 | 0.1237 | 0.1791 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.041 | 0.1985 | 1 |
Echinococcus granulosus | DNA topoisomerase 3 alpha | 0.0125 | 0.0289 | 0.0589 |
Loa Loa (eye worm) | hypothetical protein | 0.0285 | 0.1237 | 0.5592 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.041 | 0.1985 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.115 | 0.6399 | 0.6292 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.041 | 0.1985 | 0.1747 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.041 | 0.1985 | 1 |
Trichomonas vaginalis | prokaryotic DNA topoisomerase, putative | 0.0125 | 0.0289 | 0.0589 |
Echinococcus granulosus | DNA topoisomerase 3 beta 1 | 0.0125 | 0.0289 | 0.0589 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0604 | 0.3142 | 1 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.041 | 0.1985 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.1014 | 0.5586 | 1 |
Schistosoma mansoni | DNA topoisomerase II | 0.041 | 0.1985 | 1 |
Echinococcus granulosus | furin | 0.0177 | 0.0596 | 0.2296 |
Giardia lamblia | DNA topoisomerase II | 0.0355 | 0.1657 | 1 |
Echinococcus granulosus | neuroendocrine convertase 2 | 0.0111 | 0.0204 | 0.0121 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.1014 | 0.5586 | 1 |
Plasmodium falciparum | DNA gyrase subunit B | 0.1754 | 1 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.1754 | 1 | 1 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.1754 | 1 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0285 | 0.1237 | 0.1791 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.1754 | 1 | 1 |
Loa Loa (eye worm) | endoprotease bli-4 | 0.0177 | 0.0596 | 0.1814 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.1754 | 1 | 0.5 |
Schistosoma mansoni | subfamily S8B unassigned peptidase (S08 family) | 0.0177 | 0.0596 | 0.3004 |
Trichomonas vaginalis | prokaryotic DNA topoisomerase, putative | 0.0125 | 0.0289 | 0.0589 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.041 | 0.1985 | 0.1747 |
Leishmania major | DNA topoisomerase ii | 0.0285 | 0.1237 | 0.1791 |
Brugia malayi | Probable DNA topoisomerase II | 0.041 | 0.1985 | 1 |
Echinococcus multilocularis | 0.0143 | 0.0392 | 0.1164 | |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.041 | 0.1985 | 1 |
Brugia malayi | GRF zinc finger family protein | 0.0125 | 0.0289 | 0.0474 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.041 | 0.1985 | 1 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0285 | 0.1237 | 0.1791 |
Schistosoma mansoni | prokaryotic DNA topoisomerase | 0.0125 | 0.0289 | 0.1454 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.1754 | 1 | 1 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.041 | 0.1985 | 0.3202 |
Brugia malayi | DNA topoisomerase III | 0.0125 | 0.0289 | 0.0474 |
Trypanosoma brucei | DNA topoisomerase ii | 0.1014 | 0.5586 | 1 |
Schistosoma mansoni | prokaryotic DNA topoisomerase | 0.0125 | 0.0289 | 0.1454 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.0596 | 0.1814 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.041 | 0.1985 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 3.3 nM | Inhibition of furin | ChEMBL. | 22682919 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.