Detailed information for compound 1655101

Basic information

Technical information
  • TDR Targets ID: 1655101
  • Name: 6-methoxy-9H-carbazole-3-carbaldehyde
  • MW: 225.243 | Formula: C14H11NO2
  • H donors: 1 H acceptors: 1 LogP: 2.82 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)c1cc(C=O)ccc1[nH]2
  • InChi: 1S/C14H11NO2/c1-17-10-3-5-14-12(7-10)11-6-9(8-16)2-4-13(11)15-14/h2-8,15H,1H3
  • InChiKey: MPGLRLBJCNRDKU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-methoxy-9H-carbazole-3-carboxaldehyde
  • 9H-Carbazole-3-carboxaldehyde, 6-methoxy-
  • AIDS-287168
  • AIDS287168

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0059 1 1
Mycobacterium ulcerans hypothetical protein 0.0016 0 0.5
Leishmania major protein kinase, putative 0.0059 1 1
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0059 1 1
Mycobacterium ulcerans hypothetical protein 0.0016 0 0.5
Plasmodium vivax serine/threonine kinase-1, putative 0.0059 1 1
Mycobacterium ulcerans FAD-linked oxidoreductase 0.0016 0 0.5
Trichomonas vaginalis CMGC family protein kinase 0.0059 1 0.5
Mycobacterium ulcerans oxidoreductase 0.0016 0 0.5
Plasmodium falciparum protein serine/threonine kinase-1 0.0059 1 1
Chlamydia trachomatis monooxygenase 0.0016 0 0.5
Echinococcus multilocularis 0.0058 0.9894 0.9894
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0059 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0059 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0016 0 0.5
Mycobacterium ulcerans hypothetical protein 0.0016 0 0.5
Mycobacterium ulcerans oxidoreductase 0.0016 0 0.5
Giardia lamblia Kinase, CMGC CLK 0.0059 1 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0059 1 1
Leishmania major protein kinase, putative 0.0059 1 1
Echinococcus granulosus hypothetical protein 0.0058 0.9894 0.9894
Echinococcus multilocularis dual specificity protein kinase clk2 0.0059 1 1
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0059 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0016 0 0.5
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0059 1 1
Mycobacterium tuberculosis Possible oxidoreductase 0.0016 0 0.5
Mycobacterium tuberculosis Possible oxidoreductase 0.0016 0 0.5
Echinococcus granulosus dual specificity protein kinase clk2 0.0059 1 1
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0059 1 1
Mycobacterium tuberculosis Possible oxidoreductase 0.0016 0 0.5
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0059 1 1
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0059 1 1
Wolbachia endosymbiont of Brugia malayi 2-polyprenyl-6-methoxyphenol 4-hydroxylase 0.0016 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0058 0.9894 0.9894
Mycobacterium ulcerans FAD-dependent oxidoreductase 0.0016 0 0.5
Mycobacterium ulcerans oxidoreductase GMC-type 0.0016 0 0.5
Mycobacterium leprae possibleputative FAD-linked oxidoreductase 0.0016 0 0.5
Mycobacterium ulcerans membrane-associated oxidoreductase 0.0016 0 0.5

Activities

Activity type Activity value Assay description Source Reference
MIC90 (functional) = 15.6 ug ml-1 Antimycobacterial activity against Mycobacterium tuberculosis H37Rv LITERATURE. No reference
MIC90 (functional) = 99 uM Antimycobacterial activity against Mycobacterium tuberculosis H37Rv by microplate alamar blue assay ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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