Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Hepatitis C virus | Hepatitis C virus NS5B RNA-dependent RNA polymerase | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative | 0.0034 | 0.034 | 0.1594 |
Echinococcus multilocularis | cathepsin b | 0.0158 | 1 | 1 |
Trypanosoma brucei | DNA repair and recombination helicase protein PIF7 | 0.0034 | 0.034 | 0.1594 |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF7, putative | 0.0034 | 0.034 | 0.034 |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0057 | 0.2134 | 0.2134 |
Onchocerca volvulus | Cathepsin L homolog | 0.0029 | 0 | 0.5 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0158 | 1 | 1 |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF6, putative | 0.0034 | 0.034 | 0.034 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0029 | 0 | 0.5 |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0057 | 0.2134 | 1 |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0057 | 0.2134 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0057 | 0.2134 | 0.2134 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0029 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0034 | 0.034 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0057 | 0.2134 | 1 |
Entamoeba histolytica | DNA repair and recombination protein, putative | 0.0034 | 0.034 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0057 | 0.2134 | 0.2134 |
Plasmodium vivax | vivapain-2 | 0.0029 | 0 | 0.5 |
Plasmodium vivax | vivapain-2 | 0.0029 | 0 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0158 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0158 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.0158 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0057 | 0.2134 | 1 |
Echinococcus granulosus | cathepsin b | 0.0158 | 1 | 1 |
Echinococcus granulosus | ATP dependent DNA helicase PIF1 | 0.0034 | 0.034 | 0.034 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0029 | 0 | 0.5 |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Toxoplasma gondii | cathepsin B | 0.0057 | 0.2134 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0029 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0034 | 0.034 | 0.1594 |
Onchocerca volvulus | Cathepsin F homolog | 0.0029 | 0 | 0.5 |
Leishmania major | PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative | 0.0034 | 0.034 | 0.1594 |
Giardia lamblia | Cathepsin B precursor | 0.0057 | 0.2134 | 1 |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Trypanosoma brucei | DNA repair and recombination helicase protein PIF6 | 0.0034 | 0.034 | 0.1594 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0158 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.034 | 0.034 |
Echinococcus multilocularis | ATP dependent DNA helicase PIF1 | 0.0034 | 0.034 | 0.034 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0158 | 1 | 1 |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF7, putative | 0.0034 | 0.034 | 0.034 |
Giardia lamblia | Cathepsin B precursor | 0.0057 | 0.2134 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0158 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (binding) | = 760 nM | Surface Plasmon Resonance (SPR)-Based Assay | BINDINGDB. | No reference |
kon (binding) | = 4800 M-1-s-1 | Surface Plasmon Resonance (SPR)-Based Assay | BINDINGDB. | No reference |
k_off (binding) | = 0.0037 s-1 | Surface Plasmon Resonance (SPR)-Based Assay | BINDINGDB. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.