Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carbonic anhydrase VII | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase XIV | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase IX | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | carbonic anhydrase-like protein | carbonic anhydrase I | 261 aa | 281 aa | 25.3 % |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | carbonic anhydrase VII | 208 aa | 212 aa | 33.0 % |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | carbonic anhydrase II | 260 aa | 259 aa | 32.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | ShTK domain-containing protein | 0.1289 | 0.5 | 0.5 |
Loa Loa (eye worm) | tyrosinase 1 | 0.1289 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosinase precursor | 0.1289 | 0.5 | 0.5 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.1289 | 0.5 | 0.5 |
Brugia malayi | Common central domain of tyrosinase family protein | 0.1289 | 0.5 | 0.5 |
Brugia malayi | Hypothetical tyrosinase-like protein F21C3.2 in chromosome I | 0.1289 | 0.5 | 0.5 |
Onchocerca volvulus | 0.1289 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.1289 | 0.5 | 0.5 |
Onchocerca volvulus | 0.1289 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.1289 | 0.5 | 0.5 |
Onchocerca volvulus | 0.1289 | 0.5 | 0.5 | |
Schistosoma mansoni | tyrosinase precursor | 0.1289 | 0.5 | 0.5 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.1289 | 0.5 | 0.5 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.1289 | 0.5 | 0.5 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.1289 | 0.5 | 0.5 |
Onchocerca volvulus | 0.1289 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 5.1 nM | Inhibition of human recombinant full length CA1-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay | ChEMBL. | 22443141 |
Ki (binding) | = 31.1 nM | Inhibition of human recombinant full length CA2-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay | ChEMBL. | 22443141 |
Ki (binding) | = 46.9 nM | Inhibition of human recombinant full length CA14-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay | ChEMBL. | 22443141 |
Ki (binding) | = 51.5 nM | Inhibition of human recombinant CA9 catalytic domain-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay | ChEMBL. | 22443141 |
Ki (binding) | = 53.6 nM | Inhibition of human recombinant full length CA7-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay | ChEMBL. | 22443141 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.