TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 354.469 | Formula: C19H22N4OS
H donors: 2 H acceptors: 2 LogP: 2.49 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: N#Cc1c(=O)[nH]c(nc1C1CCNCC1)SCc1cc(C)ccc1C
InChi: 1S/C19H22N4OS/c1-12-3-4-13(2)15(9-12)11-25-19-22-17(14-5-7-21-8-6-14)16(10-20)18(24)23-19/h3-4,9,14,21H,5-8,11H2,1-2H3,(H,22,23,24)
InChiKey: UURFXOBWODKYTC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0067	0.1838	0.5
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1838	0.5337
Leishmania major	beta tubulin	0.0111	0.3444	0.5
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1838	0.5337
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0067	0.1838	0.5337
Echinococcus multilocularis	neuropeptide Y receptor	0.0067	0.1838	0.1838
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0061	0.1602	0.4651
Brugia malayi	Tubulin beta-1 chain	0.0111	0.3444	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0067	0.1838	0.1838
Schistosoma mansoni	amine GPCR	0.0067	0.1838	0.5337
Echinococcus granulosus	tm gpcr rhodopsin	0.0067	0.1838	0.1838
Echinococcus granulosus	biogenic amine 5HT receptor	0.0067	0.1838	0.1838
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0067	0.1838	0.5
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0067	0.1838	0.1838
Schistosoma mansoni	neuropeptide F-like receptor	0.0067	0.1838	0.5337
Echinococcus multilocularis	G protein coupled receptor 139	0.0067	0.1838	0.1838
Echinococcus granulosus	neuropeptides capa receptor	0.0067	0.1838	0.1838
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0067	0.1838	0.1838
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1838	0.5337
Brugia malayi	hypothetical protein	0.0067	0.1838	0.5337
Schistosoma mansoni	growth hormone secretagogue receptor	0.0067	0.1838	0.5337
Echinococcus granulosus	g protein coupled receptor	0.0067	0.1838	0.1838
Echinococcus multilocularis	neuropeptide receptor	0.0067	0.1838	0.1838
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0067	0.1838	0.1838
Echinococcus granulosus	tubulin subunit beta	0.0111	0.3444	0.3444
Echinococcus granulosus	Tubulin beta 2C chain	0.0111	0.3444	0.3444
Loa Loa (eye worm)	hypothetical protein	0.0053	0.1304	0.3786
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1838	0.5337
Loa Loa (eye worm)	neuropeptide F receptor	0.0067	0.1838	0.5337
Echinococcus granulosus	7TM GPCR rhodopsin	0.0067	0.1838	0.1838
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0067	0.1838	0.5337
Brugia malayi	hypothetical protein	0.0067	0.1838	0.5337
Brugia malayi	hypothetical protein	0.0067	0.1838	0.5337
Onchocerca volvulus		0.0067	0.1838	0.5
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0061	0.1602	0.4651
Schistosoma mansoni	neuropeptide receptor	0.0067	0.1838	0.5337
Echinococcus multilocularis	neuropeptide receptor	0.0067	0.1838	0.1838
Schistosoma mansoni	opsin-like receptor	0.0067	0.1838	0.5337
Schistosoma mansoni	voltage-gated potassium channel	0.0067	0.1809	0.5252
Loa Loa (eye worm)	tubulin beta-2A chain	0.0111	0.3444	1
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1838	0.5337
Echinococcus multilocularis	neuropeptide receptor A26	0.0067	0.1838	0.1838
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1838	0.5337
Leishmania major	beta tubulin	0.0111	0.3444	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0067	0.1838	0.5337
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1838	0.5337
Loa Loa (eye worm)	tubulin beta chain	0.0111	0.3444	1
Trypanosoma brucei	beta tubulin	0.0111	0.3444	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0067	0.1838	0.1838
Schistosoma mansoni	amine GPCR	0.0067	0.1838	0.5337
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0067	0.1838	0.1838
Leishmania major	beta tubulin	0.0111	0.3444	0.5
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0067	0.1838	0.5337
Echinococcus multilocularis	g protein coupled receptor	0.0067	0.1838	0.1838
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1838	0.5337
Echinococcus granulosus	rhodopsin orphan GPCR	0.0067	0.1838	0.1838
Echinococcus granulosus	neuropeptide FF receptor 2	0.0067	0.1838	0.1838
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0067	0.1838	0.5337
Echinococcus multilocularis	Tubulin beta 2C chain	0.0111	0.3444	0.3444
Leishmania major	beta tubulin	0.0111	0.3444	0.5
Schistosoma mansoni	neuropeptide f receptor 76f	0.0067	0.1838	0.5337
Echinococcus granulosus	Tubulin beta 2C chain	0.0111	0.3444	0.3444
Echinococcus granulosus	neuropeptide receptor A26	0.0067	0.1838	0.1838
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1838	0.5337
Schistosoma mansoni	tubulin subunit beta	0.0111	0.3444	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0067	0.1838	0.5337
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0067	0.1838	0.1838
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1838	0.5337
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1838	0.5337
Echinococcus multilocularis	g-protein coupled receptor	0.0067	0.1838	0.1838
Brugia malayi	G-protein coupled receptor	0.0067	0.1838	0.5337
Echinococcus granulosus	tubulin beta 1 chain	0.0111	0.3444	0.3444
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0067	0.1838	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0067	0.1838	0.1838
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0067	0.1838	0.1838
Echinococcus multilocularis	allatostatin A receptor	0.0067	0.1838	0.1838
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1838	0.5337
Loa Loa (eye worm)	TYRA-2 protein	0.0067	0.1838	0.5337
Leishmania major	beta tubulin	0.0111	0.3444	0.5
Brugia malayi	hypothetical protein	0.0067	0.1838	0.5337
Echinococcus granulosus	rhodopsin orphan GPCR	0.0067	0.1838	0.1838
Trichomonas vaginalis	tubulin gamma chain, putative	0.0111	0.3444	1
Schistosoma mansoni	opsin-like receptor	0.0067	0.1838	0.5337
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0067	0.1838	0.1838
Giardia lamblia	Beta tubulin	0.0111	0.3444	0.5
Echinococcus multilocularis	tubulin subunit beta	0.0111	0.3444	0.3444
Schistosoma mansoni	neuropeptide F-like receptor	0.0067	0.1838	0.5337
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0067	0.1838	0.5337
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1838	0.5337
Echinococcus multilocularis	g protein coupled receptor	0.0067	0.1838	0.1838
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1838	0.5337
Echinococcus multilocularis	beta tubulin	0.0111	0.3444	0.3444
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0067	0.1838	0.1838
Brugia malayi	hypothetical protein	0.0067	0.1838	0.5337
Giardia lamblia	Beta tubulin	0.0111	0.3444	0.5
Loa Loa (eye worm)	G-protein coupled receptor	0.0067	0.1838	0.5337
Toxoplasma gondii	beta tubulin	0.0111	0.3444	0.5
Leishmania major	beta tubulin	0.0111	0.3444	0.5
Entamoeba histolytica	tubulin family protein	0.0111	0.3444	0.5
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0111	0.3444	0.3444
Onchocerca volvulus		0.0067	0.1838	0.5
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0111	0.3444	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0067	0.1838	0.5337
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1838	0.5337
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1838	0.5337
Schistosoma mansoni	tubulin subunit beta	0.0111	0.3444	1
Echinococcus granulosus	beta tubulin	0.0111	0.3444	0.3444
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0067	0.1838	0.1838
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1838	0.5337
Echinococcus granulosus	neuropeptide Y receptor	0.0067	0.1838	0.1838
Echinococcus granulosus	g protein coupled receptor	0.0067	0.1838	0.1838
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1838	0.5337
Echinococcus multilocularis	Tubulin beta 2C chain	0.0111	0.3444	0.3444
Brugia malayi	sulfakinin receptor protein	0.0067	0.1838	0.5337
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0067	0.1838	0.5337
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0067	0.1838	0.5337
Brugia malayi	RE15519p	0.0067	0.1838	0.5337
Brugia malayi	G protein-coupled receptor F59B2.13	0.0067	0.1838	0.5337
Schistosoma mansoni	amine GPCR	0.0067	0.1838	0.5337
Onchocerca volvulus		0.0067	0.1838	0.5
Echinococcus multilocularis	orexin receptor type 2	0.0067	0.1838	0.1838
Schistosoma mansoni	neuropeptide receptor	0.0067	0.1838	0.5337
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0067	0.1838	0.1838
Plasmodium falciparum	tubulin beta chain	0.0111	0.3444	0.5
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1838	0.5337
Schistosoma mansoni	myosin xvIII	0.0067	0.1838	0.5337
Echinococcus multilocularis	sex peptide receptor	0.0067	0.1838	0.1838
Brugia malayi	hypothetical protein	0.0067	0.1838	0.5337
Brugia malayi	Dopamine receptor protein 1	0.0067	0.1838	0.5337
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0067	0.1838	0.5337
Echinococcus multilocularis	Tubulin beta 2C chain	0.0111	0.3444	0.3444
Echinococcus granulosus	hypothetical protein	0.0067	0.1838	0.1838
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1838	0.5337
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1838	0.5337
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0067	0.1838	0.1838
Echinococcus granulosus	rhodopsin orphan GPCR	0.0067	0.1838	0.1838
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0067	0.1838	0.1838
Brugia malayi	Melatonin receptor type 1A	0.0067	0.1838	0.5337
Brugia malayi	Dopamine receptor	0.0067	0.1838	0.5337
Echinococcus granulosus	rhodopsin orphan GPCR	0.0067	0.1838	0.1838
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1838	0.5337
Leishmania major	beta tubulin	0.0111	0.3444	0.5
Brugia malayi	putative neuropeptide receptor	0.0067	0.1838	0.5337
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0067	0.1838	0.1838
Toxoplasma gondii	beta-tubulin, putative	0.0111	0.3444	0.5
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1838	0.5337
Plasmodium vivax	tubulin beta chain, putative	0.0111	0.3444	0.5
Leishmania major	beta tubulin	0.0111	0.3444	0.5
Onchocerca volvulus		0.0067	0.1838	0.5
Brugia malayi	neuropeptide F receptor	0.0067	0.1838	0.5337
Echinococcus multilocularis	Tubulin beta 2C chain	0.0111	0.3444	0.3444
Brugia malayi	Serotonin receptor	0.0067	0.1838	0.5337
Onchocerca volvulus		0.0067	0.1838	0.5
Echinococcus multilocularis	dro:myosuppressin receptor	0.0067	0.1838	0.1838
Schistosoma mansoni	tubulin subunit beta	0.0111	0.3444	1
Echinococcus granulosus	tubulin beta 4A class IVa	0.0111	0.3444	0.3444
Echinococcus multilocularis	somatostatin receptor	0.0067	0.1838	0.1838
Leishmania major	beta tubulin	0.0111	0.3444	0.5
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1838	0.5337
Entamoeba histolytica	tubulin family protein	0.0111	0.3444	0.5
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1838	0.5337
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1838	0.5337
Echinococcus multilocularis	neuropeptide Y receptor	0.0067	0.1838	0.1838
Onchocerca volvulus		0.0067	0.1838	0.5
Schistosoma mansoni	neuropeptide receptor	0.0067	0.1838	0.5337
Echinococcus granulosus	Tubulin beta 2C chain	0.0111	0.3444	0.3444
Onchocerca volvulus		0.0067	0.1838	0.5
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0061	0.1602	0.1602
Echinococcus granulosus	neuropeptide Y receptor	0.0067	0.1838	0.1838
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0067	0.1838	0.5337
Echinococcus multilocularis	serotonin receptor	0.0067	0.1838	0.1838
Echinococcus granulosus	serotonin receptor	0.0067	0.1838	0.1838
Schistosoma mansoni	tubulin subunit beta	0.0111	0.3444	1
Onchocerca volvulus		0.0067	0.1838	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0067	0.1838	0.1838
Loa Loa (eye worm)	beta-tubulin	0.0111	0.3444	1
Echinococcus granulosus	neuropeptide s receptor	0.0067	0.1838	0.1838
Echinococcus granulosus	beta tubulin	0.0111	0.3444	0.3444
Leishmania major	beta tubulin	0.0111	0.3444	0.5
Onchocerca volvulus		0.0067	0.1838	0.5
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0067	0.1838	0.1838
Echinococcus granulosus	somatostatin receptor	0.0067	0.1838	0.1838
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0067	0.1838	0.5337
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0067	0.1838	0.5337
Brugia malayi	AKH receptor	0.0067	0.1838	0.5337
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0067	0.1838	0.5337
Giardia lamblia	Beta tubulin	0.0111	0.3444	0.5
Trichomonas vaginalis	tubulin beta chain, putative	0.0111	0.3444	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0067	0.1838	0.1838
Schistosoma mansoni	amine GPCR	0.0067	0.1838	0.5337
Onchocerca volvulus		0.0067	0.1838	0.5
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0067	0.1838	0.5337
Onchocerca volvulus		0.0067	0.1838	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0067	0.1838	0.1838
Trypanosoma brucei	beta tubulin	0.0111	0.3444	0.5
Loa Loa (eye worm)	tubulin beta-4 chain	0.0111	0.3444	1
Brugia malayi	neuropeptide F receptor	0.0067	0.1838	0.5337
Loa Loa (eye worm)	melatonin receptor type 1A	0.0067	0.1838	0.5337
Brugia malayi	hypothetical protein	0.0067	0.1838	0.5337
Schistosoma mansoni	histamine h1 receptor	0.0067	0.1838	0.5337
Echinococcus granulosus	Tubulin beta 2C chain	0.0111	0.3444	0.3444
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1838	0.5337
Echinococcus multilocularis	g protein coupled receptor	0.0067	0.1838	0.1838
Trichomonas vaginalis	tubulin alpha chain, putative	0.0111	0.3444	1
Brugia malayi	G-protein coupled receptor	0.0067	0.1838	0.5337
Schistosoma mansoni	biogenic amine receptor	0.0067	0.1838	0.5337
Echinococcus granulosus	orexin receptor type 2	0.0067	0.1838	0.1838
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0067	0.1838	0.5337
Trichomonas vaginalis	tubulin, putative	0.0111	0.3444	1
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1838	0.5337
Echinococcus granulosus	Tubulin beta 2C chain	0.0111	0.3444	0.3444
Echinococcus granulosus	7tm_1 domain containing protein	0.0067	0.1838	0.1838
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0067	0.1838	0.1838
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0067	0.1838	0.1838
Echinococcus multilocularis	tubulin beta 1 chain	0.0111	0.3444	0.3444
Echinococcus multilocularis	beta tubulin	0.0111	0.3444	0.3444
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0067	0.1838	0.5337
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0067	0.1838	0.5337
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0067	0.1838	0.5337
Trypanosoma brucei	beta tubulin	0.0111	0.3444	0.5
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0067	0.1838	0.5337
Brugia malayi	Serotonin receptor	0.0067	0.1838	0.5337
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1838	0.5337
Echinococcus granulosus	allatostatin A receptor	0.0067	0.1838	0.1838
Onchocerca volvulus		0.0067	0.1838	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0067	0.1838	0.1838
Brugia malayi	hypothetical protein	0.0067	0.1838	0.5337
Echinococcus multilocularis	fmrfamide receptor	0.0067	0.1838	0.1838
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1838	0.5337
Leishmania major	beta tubulin	0.0111	0.3444	0.5
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0067	0.1838	0.5337
Echinococcus multilocularis	serotonin receptor	0.0067	0.1838	0.1838
Loa Loa (eye worm)	BEN-1 protein	0.0111	0.3444	1
Schistosoma mansoni	hypothetical protein	0.0067	0.1838	0.5337
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1838	0.5337
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0067	0.1838	0.1838
Loa Loa (eye worm)	neuropeptide F receptor	0.0067	0.1838	0.5337
Echinococcus granulosus	neuropeptide receptor	0.0067	0.1838	0.1838
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0067	0.1838	0.1838
Trypanosoma brucei	beta tubulin	0.0111	0.3444	0.5
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1838	0.5337
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0061	0.1602	0.1602
Brugia malayi	follicle stimulating hormone receptor	0.0067	0.1838	0.5337
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1838	0.5337
Echinococcus granulosus	g protein coupled receptor	0.0067	0.1838	0.1838
Brugia malayi	larval opioid receptor	0.0067	0.1838	0.5337
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0067	0.1838	0.1838
Brugia malayi	GnHR receptor homolog	0.0067	0.1838	0.5337
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0067	0.1838	0.1838
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1838	0.5337
Echinococcus multilocularis	fmrfamide receptor	0.0067	0.1838	0.1838
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0067	0.1838	0.5337
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1838	0.5337
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0067	0.1838	0.1838
Echinococcus granulosus	biogenic amine 5HT receptor	0.0067	0.1838	0.1838
Echinococcus granulosus	rhodopsin orphan GPCR	0.0067	0.1838	0.1838
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0067	0.1838	0.5337
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1838	0.5337
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0067	0.1838	0.1838
Brugia malayi	beta-tubulin, identical	0.0111	0.3444	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0067	0.1838	0.5337
Schistosoma mansoni	voltage-gated potassium channel	0.0067	0.1809	0.5252
Brugia malayi	ORL1-like opioid receptor	0.0067	0.1838	0.5337
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0067	0.1838	0.5337
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0067	0.1838	0.5337
Schistosoma mansoni	tubulin subunit beta	0.0111	0.3444	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0067	0.1838	0.1838
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0067	0.1838	0.1838
Schistosoma mansoni	hypothetical protein	0.0067	0.1838	0.5337
Schistosoma mansoni	hypothetical protein	0.0067	0.1838	0.5337
Toxoplasma gondii	beta-1 tubulin, putative	0.0111	0.3444	0.5
Brugia malayi	hypothetical protein	0.0067	0.1838	0.5337
Loa Loa (eye worm)	tubulin beta-1 chain	0.0111	0.3444	1
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1838	0.5337
Brugia malayi	putative neuropeptide receptor NPR1	0.0067	0.1838	0.5337
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0067	0.1838	0.1838
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0067	0.1838	0.5337
Echinococcus multilocularis	neuropeptide s receptor	0.0067	0.1838	0.1838
Schistosoma mansoni	opsin-like receptor	0.0067	0.1838	0.5337
Onchocerca volvulus		0.0067	0.1838	0.5
Echinococcus granulosus	fmrfamide receptor	0.0067	0.1838	0.1838
Leishmania major	beta tubulin	0.0111	0.3444	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0067	0.1838	0.5337
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1838	0.5337
Brugia malayi	Dopamine receptor protein 2	0.0067	0.1838	0.5337
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0067	0.1838	0.5337
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0067	0.1838	0.5337
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0067	0.1838	0.5337
Leishmania major	beta tubulin	0.0111	0.3444	0.5
Schistosoma mansoni	hypothetical protein	0.0067	0.1838	0.5337
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0067	0.1838	0.5337
Leishmania major	beta tubulin	0.0111	0.3444	0.5
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1838	0.5337
Schistosoma mansoni	tubulin subunit beta	0.0111	0.3444	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0067	0.1838	0.1838
Echinococcus granulosus	g-protein coupled receptor	0.0067	0.1838	0.1838
Schistosoma mansoni	neuropeptide receptor	0.0067	0.1838	0.5337
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0067	0.1838	0.5337
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0067	0.1838	0.1838
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1838	0.5337
Brugia malayi	G protein-coupled receptor	0.0067	0.1838	0.5337
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1838	0.5337
Leishmania major	beta tubulin	0.0111	0.3444	0.5
Schistosoma mansoni	biogenic amine receptor	0.0067	0.1838	0.5337
Leishmania major	beta tubulin	0.0111	0.3444	0.5
Loa Loa (eye worm)	G-protein coupled receptor	0.0067	0.1838	0.5337
Schistosoma mansoni	adenoreceptor	0.0067	0.1838	0.5337
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1838	0.5337
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0067	0.1838	0.1838
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0067	0.1838	0.1838
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0067	0.1838	0.1838
Leishmania major	beta tubulin	0.0111	0.3444	0.5
Brugia malayi	hypothetical protein	0.0067	0.1838	0.5337
Echinococcus granulosus	neuropeptide receptor	0.0067	0.1838	0.1838
Schistosoma mansoni	biogenic amine receptor	0.0067	0.1838	0.5337
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1838	0.5337
Echinococcus granulosus	sex peptide receptor	0.0067	0.1838	0.1838
Onchocerca volvulus		0.0067	0.1838	0.5
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0111	0.3444	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0111	0.3444	0.3444
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1838	0.5337
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0067	0.1838	0.5337
Trypanosoma cruzi	beta tubulin, putative	0.0111	0.3444	0.5
Schistosoma mansoni	amine GPCR	0.0067	0.1838	0.5337
Echinococcus multilocularis	neuropeptides capa receptor	0.0067	0.1838	0.1838
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1838	0.5337
Onchocerca volvulus		0.0067	0.1838	0.5
Loa Loa (eye worm)	BEN-1 protein	0.0111	0.3444	1
Leishmania major	beta tubulin	0.0111	0.3444	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.0288	1	1
Onchocerca volvulus		0.0067	0.1838	0.5
Echinococcus granulosus	G protein coupled receptor 139	0.0067	0.1838	0.1838
Echinococcus granulosus	dro:myosuppressin receptor	0.0067	0.1838	0.1838
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0067	0.1838	0.5337

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 300 uM	Competitive inhibition of Epac2 using fluorescent nucleotide analog 8-NBD-cAMP by fluorescence analysis	ChEMBL.	22607683

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2030615

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1655751