Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | nAChR subunit | 0.0133 | 0.0865 | 0.2694 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0133 | 0.0865 | 0.4318 |
Onchocerca volvulus | 0.0133 | 0.0865 | 1 | |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0133 | 0.0865 | 0.0865 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0865 | 0.0838 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0133 | 0.0865 | 0.4318 |
Brugia malayi | bZIP transcription factor family protein | 0.0099 | 0.0339 | 0.0339 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0865 | 0.0838 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0133 | 0.0865 | 0.0865 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0133 | 0.0865 | 0.0865 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0133 | 0.0865 | 0.4318 |
Brugia malayi | Cytochrome P450 family protein | 0.0149 | 0.1122 | 0.1122 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0865 | 0.0838 |
Schistosoma mansoni | nAChR subunit | 0.0133 | 0.0865 | 0.2694 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0133 | 0.0865 | 0.4318 |
Loa Loa (eye worm) | hypothetical protein | 0.0708 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0865 | 0.0838 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0865 | 0.0838 |
Brugia malayi | Cytochrome P450 family protein | 0.0149 | 0.1122 | 0.1122 |
Schistosoma mansoni | fatty acid binding protein | 0.0202 | 0.197 | 0.6318 |
Onchocerca volvulus | 0.0133 | 0.0865 | 1 | |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0133 | 0.0865 | 0.0838 |
Trypanosoma brucei | cytochrome P450, putative | 0.0149 | 0.1122 | 0.5 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0133 | 0.0865 | 0.4318 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0133 | 0.0865 | 0.0838 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0133 | 0.0865 | 0.0838 |
Schistosoma mansoni | fatty acid binding protein | 0.0202 | 0.197 | 0.6318 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0133 | 0.0865 | 0.4318 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0133 | 0.0865 | 0.4318 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0865 | 0.0838 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0133 | 0.0865 | 0.4318 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0133 | 0.0865 | 0.4318 |
Echinococcus granulosus | jun protein | 0.0099 | 0.0339 | 0.1614 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0351 | 0.4329 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0133 | 0.0865 | 0.4318 |
Schistosoma mansoni | nAChR subunit | 0.0133 | 0.0865 | 0.2694 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0865 | 0.0838 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0149 | 0.1122 | 0.1096 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0133 | 0.0865 | 0.0865 |
Mycobacterium ulcerans | glutaminase | 0.0273 | 0.3092 | 0.6144 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0149 | 0.1122 | 0.5 |
Echinococcus multilocularis | fatty acid binding protein FABP2 | 0.0202 | 0.197 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0133 | 0.0865 | 0.0865 |
Echinococcus granulosus | fatty acid binding protein FABP2 | 0.0202 | 0.197 | 1 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0133 | 0.0865 | 0.2694 |
Loa Loa (eye worm) | ACC-1 protein | 0.0133 | 0.0865 | 0.0838 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0296 | 0.0267 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0133 | 0.0865 | 0.4318 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0139 | 0.0972 | 0.4872 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0133 | 0.0865 | 0.2694 |
Brugia malayi | Lipocalin / cytosolic fatty-acid binding protein family protein | 0.0698 | 0.9844 | 0.9844 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0149 | 0.1122 | 0.1096 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0133 | 0.0865 | 0.0865 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0133 | 0.0865 | 0.0838 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0865 | 0.0838 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0865 | 0.0838 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0351 | 0.4329 | 1 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0133 | 0.0865 | 0.0838 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0133 | 0.0865 | 0.2694 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0133 | 0.0865 | 0.0865 |
Echinococcus multilocularis | nAChR subunit | 0.0133 | 0.0865 | 0.4318 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0133 | 0.0865 | 0.4318 |
Schistosoma mansoni | lipoxygenase | 0.0097 | 0.0307 | 0.0865 |
Trichomonas vaginalis | glutaminase, putative | 0.0273 | 0.3092 | 0.5 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0133 | 0.0865 | 0.2694 |
Echinococcus multilocularis | fatty acid binding protein FABP2 | 0.0202 | 0.197 | 1 |
Loa Loa (eye worm) | glutaminase | 0.0273 | 0.3092 | 0.3072 |
Loa Loa (eye worm) | lipocalin/cytosolic fatty-acid binding protein family protein | 0.0698 | 0.9844 | 0.9843 |
Loa Loa (eye worm) | hypothetical protein | 0.0647 | 0.9029 | 0.9027 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0133 | 0.0865 | 0.4318 |
Echinococcus granulosus | nAChR subunit | 0.0133 | 0.0865 | 0.4318 |
Schistosoma mansoni | nAChR subunit | 0.0133 | 0.0865 | 0.2694 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0133 | 0.0865 | 0.0865 |
Loa Loa (eye worm) | glutaminase 2 | 0.0273 | 0.3092 | 0.3072 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0133 | 0.0865 | 0.0865 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0133 | 0.0865 | 0.4318 |
Loa Loa (eye worm) | LGC-31 protein | 0.0133 | 0.0865 | 0.0838 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0139 | 0.0972 | 0.4872 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0133 | 0.0865 | 0.0865 |
Brugia malayi | Cytochrome P450 family protein | 0.0244 | 0.2625 | 0.2625 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0149 | 0.1122 | 0.1096 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0133 | 0.0865 | 0.4318 |
Brugia malayi | Cation transporter family protein | 0.0133 | 0.0865 | 0.0865 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0133 | 0.0865 | 0.4318 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0133 | 0.0865 | 0.4318 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0865 | 0.0838 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0133 | 0.0865 | 0.2694 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0865 | 0.0838 |
Brugia malayi | Cation transporter family protein | 0.0133 | 0.0865 | 0.0865 |
Schistosoma mansoni | nAChR subunit | 0.0133 | 0.0865 | 0.2694 |
Onchocerca volvulus | Putative nachr subunit | 0.0133 | 0.0865 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0133 | 0.0865 | 0.0865 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0149 | 0.1122 | 0.5 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0133 | 0.0865 | 0.0838 |
Echinococcus multilocularis | jun protein | 0.0099 | 0.0339 | 0.1614 |
Schistosoma mansoni | glutaminase | 0.0273 | 0.3092 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0133 | 0.0865 | 0.4318 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0133 | 0.0865 | 0.4318 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0099 | 0.0339 | 0.1614 |
Brugia malayi | glutaminase DH11.1 | 0.0273 | 0.3092 | 0.3092 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0865 | 0.0838 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0133 | 0.0865 | 0.0865 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0865 | 0.0838 |
Schistosoma mansoni | nAChR subunit | 0.0133 | 0.0865 | 0.2694 |
Schistosoma mansoni | lipoxygenase | 0.0139 | 0.0972 | 0.3047 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0133 | 0.0865 | 0.2694 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0133 | 0.0865 | 0.4318 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0133 | 0.0865 | 0.4318 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0133 | 0.0865 | 0.4318 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0865 | 0.0838 |
Echinococcus granulosus | fatty acid binding protein FABP2 | 0.0202 | 0.197 | 1 |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0133 | 0.0865 | 0.0865 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0133 | 0.0865 | 0.0865 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0326 | 0.3937 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0865 | 0.0838 |
Schistosoma mansoni | nAChR subunit | 0.0133 | 0.0865 | 0.2694 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0133 | 0.0865 | 0.4318 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0133 | 0.0865 | 0.0865 |
Onchocerca volvulus | 0.0133 | 0.0865 | 1 | |
Onchocerca volvulus | 0.0133 | 0.0865 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0865 | 0.0838 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0099 | 0.0339 | 0.1614 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0133 | 0.0865 | 0.0865 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0133 | 0.0865 | 0.4318 |
Brugia malayi | Cation transporter family protein | 0.0133 | 0.0865 | 0.0865 |
Onchocerca volvulus | 0.0133 | 0.0865 | 1 | |
Loa Loa (eye worm) | ACC-1 protein | 0.0133 | 0.0865 | 0.0838 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0865 | 0.0838 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0244 | 0.2625 | 0.2603 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0133 | 0.0865 | 0.4318 |
Leishmania major | cytochrome p450-like protein | 0.0149 | 0.1122 | 0.5 |
Onchocerca volvulus | 0.0133 | 0.0865 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0865 | 0.0838 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.