Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma | Starlite/ChEMBL | References |
Homo sapiens | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta | Starlite/ChEMBL | References |
Homo sapiens | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | 1068 aa | 927 aa | 29.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0587 | 0.5263 | 1 |
Echinococcus granulosus | activated cdc42 kinase 1 | 0.1011 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1006 | 0.9942 | 0.9942 |
Loa Loa (eye worm) | hypothetical protein | 0.1011 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0387 | 0.3036 | 0.3036 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.1448 | 0.1448 |
Loa Loa (eye worm) | hypothetical protein | 0.0392 | 0.3093 | 0.3093 |
Loa Loa (eye worm) | hypothetical protein | 0.0387 | 0.3036 | 0.3036 |
Echinococcus multilocularis | phosphatidylinositol 4,5 bisphosphate 3 kinase | 0.0587 | 0.5263 | 0.446 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0378 | 0.2937 | 0.2847 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0392 | 0.3093 | 0.1924 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0378 | 0.2937 | 1 |
Echinococcus multilocularis | activated cdc42 kinase 1 | 0.1011 | 1 | 1 |
Trypanosoma brucei | phosphatidylinositol 3-kinase, putative | 0.0127 | 0.0125 | 0.5 |
Echinococcus multilocularis | transfer RNA-Thr | 0.1011 | 1 | 1 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase vps34-like | 0.0127 | 0.0125 | 0.0426 |
Entamoeba histolytica | phosphatidylinositol 3-kinase 1, putative | 0.0367 | 0.2812 | 0.9555 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.026 | 0.1614 | 0.5294 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0378 | 0.2937 | 1 |
Trichomonas vaginalis | phopsphatidylinositol 3-kinase, drosophila, putative | 0.0378 | 0.2937 | 1 |
Brugia malayi | phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative | 0.0208 | 0.1038 | 0.0924 |
Echinococcus granulosus | activated cdc42 kinase 1 | 0.1011 | 1 | 1 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0245 | 0.1448 | 0.134 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0378 | 0.2937 | 1 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0378 | 0.2937 | 1 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.026 | 0.1614 | 0.5294 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0509 | 0.44 | 0.44 |
Echinococcus multilocularis | protein KINase family member (kin 25) | 0.0392 | 0.3093 | 0.1924 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0301 | 0.2074 | 0.6931 |
Giardia lamblia | Phosphoinositide-3-kinase, catalytic, alpha polypeptide | 0.0183 | 0.0751 | 0.5 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit gamma, putative | 0.0378 | 0.2937 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0301 | 0.2074 | 0.6931 |
Echinococcus granulosus | phosphatidylinositol 45 bisphosphate 3 kinase | 0.0587 | 0.5263 | 0.446 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.02 | 0.02 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0168 | 0.0585 | 0.1637 |
Schistosoma mansoni | tyrosine kinase | 0.0392 | 0.3093 | 0.5777 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.7 | Inhibition of PI3Kgamma assessed as inhibition of fMLP-induced neutrophil migration assay by cell based assay | ChEMBL. | 22819766 |
IC50 (binding) | = 6.3 | Inhibition of PI3Kgamma assessed as inhibition of C5a-induced AKT phosphorylation at Ser473 by cell based assay | ChEMBL. | 22819766 |
IC50 (binding) | = 6.9 | Inhibition of PI3Kdelta by high throughput chemoproteomics binding assay | ChEMBL. | 22819766 |
IC50 (binding) | > 7 | Inhibition of PI3Kalpha by high throughput chemoproteomics binding assay | ChEMBL. | 22819766 |
IC50 (binding) | = 8.1 | Inhibition of PI3Kgamma by high throughput chemoproteomics binding assay | ChEMBL. | 22819766 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.