Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | cell division protein FtsZ | 0.0973 | 1 | 0.5 |
Brugia malayi | Cell division protein ftsZ | 0.048 | 0.0265 | 0.0805 |
Mycobacterium tuberculosis | Cell division protein FtsZ | 0.0973 | 1 | 0.5 |
Echinococcus multilocularis | cyclin g associated kinase | 0.0633 | 0.3287 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0633 | 0.3287 | 1 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsZ | 0.0973 | 1 | 0.5 |
Loa Loa (eye worm) | NAK/GAK protein kinase | 0.0633 | 0.3287 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0633 | 0.3287 | 0.5 |
Echinococcus granulosus | cyclin g associated kinase | 0.0633 | 0.3287 | 0.5 |
Treponema pallidum | cell division protein FtsZ | 0.0973 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
TC50 (ADMET) | = 163 uM | Cytotoxicity in mouse RAW264.7 cells after 24 hrs by MTT assay | ChEMBL. | 22633122 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.