Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | hydroxycarboxylic acid receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | G-protein coupled receptor, putative | hydroxycarboxylic acid receptor 2 | 363 aa | 294 aa | 20.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Rhodanese-like domain containing protein | 0.0057 | 0.0841 | 0.1397 |
Trichomonas vaginalis | m-phase inducer phosphatase, putative | 0.0057 | 0.0841 | 0.0841 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0352 | 0.6021 | 1 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0188 | 0.3141 | 0.3141 |
Brugia malayi | Rhodanese-like domain containing protein | 0.0057 | 0.0841 | 0.1397 |
Trichomonas vaginalis | m-phase inducer phosphatase, putative | 0.0057 | 0.0841 | 0.0841 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0058 | 0.086 | 0.086 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0188 | 0.3141 | 0.3141 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0057 | 0.0841 | 0.0841 |
Schistosoma mansoni | m-phase inducer phosphatase(cdc25) | 0.0057 | 0.0841 | 0.1397 |
Trichomonas vaginalis | pps1 dual specificty phosphatase, putative | 0.0579 | 1 | 1 |
Onchocerca volvulus | 0.0057 | 0.0841 | 0.2679 | |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0057 | 0.0841 | 0.0841 |
Trichomonas vaginalis | cdc25c, putative | 0.0057 | 0.0841 | 0.0841 |
Onchocerca volvulus | 0.0057 | 0.0841 | 0.2679 | |
Leishmania major | hypothetical protein, conserved | 0.0058 | 0.086 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0058 | 0.086 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0058 | 0.086 | 1 |
Trichomonas vaginalis | cdc25b, putative | 0.0057 | 0.0841 | 0.0841 |
Echinococcus granulosus | m phase inducer phosphatasecdc25 | 0.0057 | 0.0841 | 0.1397 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0352 | 0.6021 | 1 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0352 | 0.6021 | 1 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0352 | 0.6021 | 1 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0352 | 0.6021 | 1 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0188 | 0.3141 | 0.3141 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0188 | 0.3141 | 0.3141 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0188 | 0.3141 | 0.3141 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0188 | 0.3141 | 0.3141 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0763 | 0.1268 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0057 | 0.0841 | 0.0841 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0841 | 0.1397 |
Onchocerca volvulus | 0.0188 | 0.3141 | 1 | |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0188 | 0.3141 | 0.3141 |
Trypanosoma brucei | low molecular weight protein tyrosine phosphatase, putative | 0.0058 | 0.086 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0841 | 0.1397 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0188 | 0.3141 | 0.3141 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0058 | 0.086 | 0.086 |
Giardia lamblia | Low molecular weight protein-tyrosine-phosphatase | 0.0188 | 0.3141 | 1 |
Mycobacterium ulcerans | phosphotyrosine protein phosphatase PtpA | 0.0188 | 0.3141 | 0.5 |
Trichomonas vaginalis | cdc25b, putative | 0.0057 | 0.0841 | 0.0841 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0057 | 0.0841 | 0.0841 |
Onchocerca volvulus | 0.0057 | 0.0841 | 0.2679 | |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0057 | 0.0841 | 0.0841 |
Mycobacterium tuberculosis | Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) | 0.013 | 0.2124 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0763 | 0.1268 |
Onchocerca volvulus | 0.0057 | 0.0841 | 0.2679 | |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0057 | 0.0841 | 0.0841 |
Loa Loa (eye worm) | phosphotyrosine protein phosphatase | 0.0188 | 0.3141 | 0.5216 |
Echinococcus multilocularis | m phase inducer phosphatase(cdc25) | 0.0057 | 0.0841 | 0.1397 |
Brugia malayi | Low molecular weight phosphotyrosine protein phosphatase containing protein | 0.0188 | 0.3141 | 0.5216 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 28 nM | Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation | ChEMBL. | 24900372 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.