Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tar DNA binding protein | 0.0064 | 0.2703 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0064 | 0.2703 | 0.2703 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.2703 | 0.8447 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0031 | 0 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0064 | 0.2703 | 0.2703 |
Echinococcus granulosus | GPCR family 2 | 0.0033 | 0.0104 | 0.0384 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.5868 | 0.5868 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0031 | 0 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0033 | 0.0104 | 0.0104 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0104 | 0.0324 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0121 | 0.7362 | 0.7362 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.2703 | 0.8447 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0121 | 0.7362 | 0.7362 |
Brugia malayi | RNA binding protein | 0.0064 | 0.2703 | 0.2703 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0104 | 0.0104 |
Brugia malayi | TAR-binding protein | 0.0064 | 0.2703 | 0.2703 |
Echinococcus multilocularis | tar DNA binding protein | 0.0064 | 0.2703 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.32 | 0.32 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.007 | 0.32 | 0.32 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0031 | 0 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0121 | 0.7362 | 0.7362 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0104 | 0.0324 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0104 | 0.0324 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0064 | 0.2703 | 0.2703 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0103 | 0.5868 | 0.5868 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0031 | 0 | 0.5 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0031 | 0 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0031 | 0 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.0104 | 0.0384 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.0104 | 0.0384 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.2703 | 0.8447 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0033 | 0.0104 | 0.0104 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0103 | 0.5868 | 0.5868 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0031 | 0 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0033 | 0.0104 | 0.0104 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.0104 | 0.0384 |
Onchocerca volvulus | 0.0153 | 1 | 0.5 | |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0103 | 0.5868 | 0.5868 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.0104 | 0.0384 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0104 | 0.0324 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.2703 | 0.8447 |
Loa Loa (eye worm) | RNA binding protein | 0.0064 | 0.2703 | 0.2703 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.2703 | 0.8447 |
Echinococcus multilocularis | GPCR, family 2 | 0.0033 | 0.0104 | 0.0384 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.32 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.