Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cholinergic receptor, muscarinic 4 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.4298 | 0.4298 |
Schistosoma mansoni | intermediate filament proteins | 0.0053 | 1 | 1 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0025 | 0.1976 | 0.1976 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0028 | 0.28 | 0.28 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.8837 | 0.8837 |
Loa Loa (eye worm) | intermediate filament protein | 0.0053 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 1 | 1 |
Leishmania major | DNA polymerase kappa, putative | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0053 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0 | 0.5 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.9716 | 0.9716 |
Leishmania major | DNA polymerase eta, putative | 0.0019 | 0 | 0.5 |
Onchocerca volvulus | 0.0053 | 1 | 0.5 | |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.8837 | 0.8837 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0028 | 0.28 | 0.28 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0 | 0.5 |
Trypanosoma brucei | unspecified product | 0.0019 | 0 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.8837 | 0.8837 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0019 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.4298 | 0.4298 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | lamin | 0.0053 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.1976 | 0.1976 |
Echinococcus multilocularis | musashi | 0.0053 | 1 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0053 | 1 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0 | 0.5 |
Onchocerca volvulus | 0.0053 | 1 | 0.5 | |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0019 | 0 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.1692 | 0.1692 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.4298 | 0.4298 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | lamin | 0.0053 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.8837 | 0.8837 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0053 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.1692 | 0.1692 |
Echinococcus multilocularis | lamin dm0 | 0.0053 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | lamin | 0.0053 | 1 | 1 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0025 | 0.1976 | 0.1976 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0019 | 0 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
%max (functional) | = 37.6 % | Positive allosteric modulation of human M4 receptor expressed in CHO-K1 cells coexpressing Gqi5 assessed as potentiation of acetylcholine-mediated calcium mobilization incubated for 144 secs prior to acetylcholine addition by Fluo-4-AM staining relative to acetylcholine | ChEMBL. | 22738637 |
EC50 (functional) | = 5.63 | Positive allosteric modulation of human M4 receptor expressed in CHO-K1 cells coexpressing Gqi5 assessed as potentiation of acetylcholine-mediated calcium mobilization incubated for 144 secs prior to acetylcholine addition by Fluo-4-AM staining | ChEMBL. | 22738637 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.