Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphodiesterase 8B | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | histone deacetylase, putative | 0.03 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase | 0.03 | 1 | 1 |
Onchocerca volvulus | 0.0042 | 0.047 | 0.5 | |
Loa Loa (eye worm) | histone deacetylase 7A | 0.03 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.03 | 1 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0042 | 0.047 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.047 | 0.047 |
Schistosoma mansoni | histone deacetylase hda2 | 0.03 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.03 | 1 | 1 |
Plasmodium vivax | histone deacetylase 2, putative | 0.03 | 1 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0042 | 0.047 | 0.047 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.03 | 1 | 1 |
Loa Loa (eye worm) | calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase | 0.0121 | 0.3395 | 0.3395 |
Trypanosoma cruzi | histone deacetylase, putative | 0.03 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.047 | 0.047 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0042 | 0.047 | 0.047 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0042 | 0.047 | 0.5 |
Echinococcus multilocularis | histone deacetylase 6 | 0.03 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.306 | 0.306 |
Plasmodium vivax | hypothetical protein, conserved | 0.0042 | 0.047 | 0.047 |
Schistosoma mansoni | camp-specific cyclic nucleotide phosphodiesterase | 0.0121 | 0.3395 | 0.3069 |
Onchocerca volvulus | 0.0042 | 0.047 | 0.5 | |
Plasmodium vivax | histone deacetylase, putative | 0.03 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.03 | 1 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.03 | 1 | 1 |
Echinococcus granulosus | histone deacetylase | 0.03 | 1 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0042 | 0.047 | 0.047 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0042 | 0.047 | 0.047 |
Plasmodium falciparum | histone deacetylase 2 | 0.03 | 1 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0042 | 0.047 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0042 | 0.047 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0042 | 0.047 | 0.5 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0042 | 0.047 | 0.5 |
Brugia malayi | 3'5'-cyclic nucleotide phosphodiesterase family protein | 0.0121 | 0.3395 | 0.3395 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.047 | 0.047 |
Loa Loa (eye worm) | hypothetical protein | 0.03 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.047 | 0.047 |
Trypanosoma cruzi | histone deacetylase, putative | 0.03 | 1 | 1 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.03 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0042 | 0.047 | 0.047 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.047 | 0.047 |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.047 | 0.047 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.047 | 0.047 |
Loa Loa (eye worm) | beta-lactamase | 0.0042 | 0.047 | 0.047 |
Plasmodium falciparum | histone deacetylase, putative | 0.03 | 1 | 1 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.03 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.306 | 0.306 |
Mycobacterium leprae | Probable lipase LipE | 0.0042 | 0.047 | 0.5 |
Trichomonas vaginalis | esterase, putative | 0.0042 | 0.047 | 0.5 |
Leishmania major | histone deacetylase, putative | 0.03 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0042 | 0.047 | 0.5 |
Trypanosoma brucei | histone deacetylase 4 | 0.03 | 1 | 1 |
Trypanosoma brucei | histone deacetylase 3 | 0.03 | 1 | 1 |
Brugia malayi | beta-lactamase | 0.0042 | 0.047 | 0.047 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.306 | 0.306 |
Loa Loa (eye worm) | histone deacetylase | 0.03 | 1 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0042 | 0.047 | 0.5 |
Mycobacterium ulcerans | lipase LipD | 0.0042 | 0.047 | 0.5 |
Leishmania major | histone deacetylase, putative | 0.03 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 7 | 0.03 | 1 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0042 | 0.047 | 0.5 |
Echinococcus multilocularis | histone deacetylase 6 | 0.03 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.047 | 0.047 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0042 | 0.047 | 0.047 |
Onchocerca volvulus | 0.0042 | 0.047 | 0.5 | |
Echinococcus multilocularis | histone deacetylase 7 | 0.03 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.3395 | 0.3395 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0042 | 0.047 | 0.047 |
Echinococcus granulosus | histone deacetylase 6 | 0.03 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.03 | 1 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.03 | 1 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0042 | 0.047 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0271 | 0.8924 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.0872 uM | Inhibition of PDE8B expressed in Sf9 insect cells | ChEMBL. | 22858141 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.