Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0568 | 0.7226 | 1 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0042 | 0.0277 | 0.4588 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0024 | 0.0043 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.003 | 0.0123 | 0.0123 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0278 | 0.3399 | 0.4492 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0127 | 0.1405 | 0.1876 |
Echinococcus multilocularis | baculoviral IAP repeat containing protein | 0.0167 | 0.1929 | 0.1929 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0278 | 0.3399 | 0.5 |
Plasmodium falciparum | histone deacetylase 2 | 0.0568 | 0.7226 | 1 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0568 | 0.7226 | 0.7209 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.003 | 0.0123 | 0.0123 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.003 | 0.0123 | 0.0123 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0568 | 0.7226 | 0.7226 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.1929 | 0.188 |
Brugia malayi | MH2 domain containing protein | 0.0127 | 0.1405 | 0.1876 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0568 | 0.7226 | 0.7226 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0278 | 0.3399 | 0.3399 |
Mycobacterium ulcerans | O-succinylbenzoate synthase | 0.0063 | 0.0554 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.003 | 0.0123 | 0.0063 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0033 | 0.0166 | 0.0166 |
Trypanosoma brucei | histone deacetylase, putative | 0.0568 | 0.7226 | 1 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0042 | 0.0277 | 0.0277 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0042 | 0.0277 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0568 | 0.7226 | 1 |
Brugia malayi | N-terminal motif family protein | 0.0192 | 0.2263 | 0.3075 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0167 | 0.1929 | 0.2608 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.003 | 0.0123 | 0.0123 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0278 | 0.3399 | 0.3347 |
Brugia malayi | eukaryotic initiation factor 4A | 0.0278 | 0.3399 | 0.4659 |
Schistosoma mansoni | inhibitor of apoptosis (iap) domain family member | 0.0167 | 0.1929 | 0.188 |
Echinococcus granulosus | histone deacetylase 7 | 0.0568 | 0.7226 | 0.7226 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.003 | 0.0123 | 0.0123 |
Echinococcus granulosus | baculoviral IAP repeat containing protein | 0.0167 | 0.1929 | 0.1929 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0568 | 0.7226 | 0.7209 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0278 | 0.3399 | 0.3399 |
Echinococcus multilocularis | histone deacetylase | 0.0568 | 0.7226 | 0.7226 |
Brugia malayi | Histone deacetylase family protein | 0.0568 | 0.7226 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0278 | 0.3399 | 1 |
Echinococcus multilocularis | inhibitor of apoptosis protein | 0.0167 | 0.1929 | 0.1929 |
Brugia malayi | Inositol-1 | 0.0042 | 0.0277 | 0.0304 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.1929 | 0.2608 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0278 | 0.3399 | 0.4492 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0278 | 0.3399 | 0.3399 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0568 | 0.7226 | 0.7226 |
Loa Loa (eye worm) | runx1 | 0.0063 | 0.0555 | 0.069 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0278 | 0.3399 | 1 |
Leishmania major | histone deacetylase, putative | 0.0568 | 0.7226 | 1 |
Leishmania major | histone deacetylase, putative | 0.0568 | 0.7226 | 1 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0278 | 0.3399 | 0.4492 |
Chlamydia trachomatis | glutamine binding protein | 0.0024 | 0.0043 | 0.5 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0778 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0499 | 0.6321 | 0.8737 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0278 | 0.3399 | 1 |
Schistosoma mansoni | lozenge | 0.0063 | 0.0555 | 0.0498 |
Trypanosoma brucei | histone deacetylase 4 | 0.0568 | 0.7226 | 1 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0037 | 0.022 | 0.0527 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0167 | 0.1929 | 0.2608 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0278 | 0.3399 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0568 | 0.7226 | 0.7226 |
Echinococcus multilocularis | Protein lozenge | 0.0063 | 0.0555 | 0.0555 |
Echinococcus multilocularis | glutamate receptor 2 | 0.003 | 0.0123 | 0.0123 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0033 | 0.0166 | 0.0166 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0568 | 0.7226 | 0.7209 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0568 | 0.7226 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0033 | 0.0166 | 0.0166 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0278 | 0.3399 | 0.3359 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.003 | 0.0123 | 0.0123 |
Echinococcus granulosus | histone deacetylase | 0.0568 | 0.7226 | 0.7226 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0278 | 0.3399 | 0.4492 |
Loa Loa (eye worm) | histone deacetylase | 0.0568 | 0.7226 | 1 |
Echinococcus granulosus | glutamate receptor 2 | 0.003 | 0.0123 | 0.0123 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0568 | 0.7226 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0278 | 0.3399 | 0.4659 |
Echinococcus granulosus | inhibitor of apoptosis protein | 0.0167 | 0.1929 | 0.1929 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0278 | 0.3399 | 0.4492 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0042 | 0.0277 | 0.0277 |
Brugia malayi | Histone deacetylase family protein | 0.0568 | 0.7226 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0025 | 0.006 | 0.006 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.1929 | 0.2608 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0778 | 1 | 1 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0278 | 0.3399 | 0.3359 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0568 | 0.7226 | 1 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0192 | 0.2263 | 0.0762 |
Plasmodium vivax | histone deacetylase, putative | 0.0568 | 0.7226 | 1 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0025 | 0.006 | 0.006 |
Echinococcus granulosus | histone deacetylase 6 | 0.0568 | 0.7226 | 0.7226 |
Trypanosoma brucei | histone deacetylase 3 | 0.0568 | 0.7226 | 1 |
Plasmodium falciparum | histone deacetylase, putative | 0.0568 | 0.7226 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0568 | 0.7226 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.003 | 0.0123 | 0.0123 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0278 | 0.3399 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.2263 | 0.3075 |
Loa Loa (eye worm) | hypothetical protein | 0.0499 | 0.6321 | 0.8737 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.003 | 0.0123 | 0.0123 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0037 | 0.022 | 0.5 |
Brugia malayi | hypothetical protein | 0.0499 | 0.6321 | 0.8737 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0278 | 0.3399 | 1 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0568 | 0.7226 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0042 | 0.0277 | 0.0219 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0568 | 0.7226 | 1 |
Loa Loa (eye worm) | inositol-1 | 0.0042 | 0.0277 | 0.0304 |
Onchocerca volvulus | 0.0499 | 0.6321 | 1 | |
Echinococcus granulosus | histone deacetylase 6 | 0.0568 | 0.7226 | 0.7226 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0025 | 0.006 | 0.006 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0127 | 0.1405 | 0.1876 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0278 | 0.3399 | 0.3399 |
Schistosoma mansoni | inhibitor of apoptosis protein | 0.0167 | 0.1929 | 0.188 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0278 | 0.3399 | 0.4492 |
Schistosoma mansoni | inositol monophosphatase | 0.0042 | 0.0277 | 0.0219 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0568 | 0.7226 | 0.7226 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 100 uM | Inhibition of KB cell growth was determined; >100 indicates IC50 greater than the noted(highest) concentration tested. | ChEMBL. | 12672244 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.