Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 27 (fatty acid transporter), member 1 | Starlite/ChEMBL | References |
Mus musculus | solute carrier family 27 (fatty acid transporter), member 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | solute carrier family 27 (fatty acid transporter), member 1 | 646 aa | 519 aa | 20.4 % |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | solute carrier family 27 (fatty acid transporter), member 1 | 646 aa | 552 aa | 22.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | FFA transport protein | 0.0224 | 0.9672 | 1 |
Echinococcus granulosus | long chain fatty acid transport protein 4 | 0.0224 | 0.9672 | 1 |
Mycobacterium ulcerans | long-chain-acyl-CoA synthetase | 0.0231 | 1 | 1 |
Trypanosoma brucei | acetyl-CoA synthetase, putative | 0.001 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0221 | 0.954 | 1 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.001 | 0 | 0.5 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.001 | 0 | 0.5 |
Leishmania major | fatty acid transporter protein-like protein | 0.0221 | 0.954 | 1 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Mycobacterium leprae | possible long-chain acyl-CoA synthase | 0.0221 | 0.954 | 1 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Trypanosoma brucei | long-chain-fatty-acid-CoA ligase, putative | 0.001 | 0 | 0.5 |
Entamoeba histolytica | long-chain-fatty-acid--CoA ligase, putative | 0.001 | 0 | 0.5 |
Plasmodium falciparum | acetyl-CoA synthetase, putative | 0.001 | 0 | 0.5 |
Toxoplasma gondii | propionate-CoA ligase | 0.001 | 0 | 0.5 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Echinococcus multilocularis | long chain fatty acid transport protein 4 | 0.0224 | 0.9672 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.001 | 0 | 0.5 |
Trypanosoma cruzi | fatty acid transporter protein-like, putative | 0.0224 | 0.9672 | 1 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.001 | 0 | 0.5 |
Toxoplasma gondii | Acetyl-coenzyme A synthetase 2, putative | 0.001 | 0 | 0.5 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.001 | 0 | 0.5 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.001 | 0 | 0.5 |
Plasmodium vivax | acetyl-CoA synthetase, putative | 0.001 | 0 | 0.5 |
Trypanosoma cruzi | fatty acid transporter protein-like, putative | 0.0224 | 0.9672 | 1 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0231 | 1 | 1 |
Onchocerca volvulus | 0.001 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.2 uM | Inhibition of mouse recombinant FATP1 acyl-coA synthetase activity using [14C]oleic acid as substrate | ChEMBL. | 22749869 |
IC50 (binding) | = 0.26 uM | Inhibition of human recombinant FATP1 acyl-coA synthetase activity using [14C]oleic acid as substrate | ChEMBL. | 22749869 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.