Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 27 (fatty acid transporter), member 1 | Starlite/ChEMBL | References |
Mus musculus | solute carrier family 27 (fatty acid transporter), member 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | solute carrier family 27 (fatty acid transporter), member 1 | 646 aa | 552 aa | 22.8 % |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | solute carrier family 27 (fatty acid transporter), member 1 | 646 aa | 519 aa | 20.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0221 | 0.954 | 1 |
Echinococcus granulosus | long chain fatty acid transport protein 4 | 0.0224 | 0.9672 | 1 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0231 | 1 | 1 |
Trypanosoma cruzi | fatty acid transporter protein-like, putative | 0.0224 | 0.9672 | 1 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.001 | 0 | 0.5 |
Toxoplasma gondii | propionate-CoA ligase | 0.001 | 0 | 0.5 |
Plasmodium falciparum | acetyl-CoA synthetase, putative | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | long chain fatty acid transport protein 4 | 0.0224 | 0.9672 | 1 |
Plasmodium vivax | acetyl-CoA synthetase, putative | 0.001 | 0 | 0.5 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.001 | 0 | 0.5 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.001 | 0 | 0.5 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Leishmania major | fatty acid transporter protein-like protein | 0.0221 | 0.954 | 1 |
Entamoeba histolytica | long-chain-fatty-acid--CoA ligase, putative | 0.001 | 0 | 0.5 |
Mycobacterium leprae | possible long-chain acyl-CoA synthase | 0.0221 | 0.954 | 1 |
Toxoplasma gondii | Acetyl-coenzyme A synthetase 2, putative | 0.001 | 0 | 0.5 |
Mycobacterium ulcerans | long-chain-acyl-CoA synthetase | 0.0231 | 1 | 1 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.001 | 0 | 0.5 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Trypanosoma cruzi | fatty acid transporter protein-like, putative | 0.0224 | 0.9672 | 1 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.001 | 0 | 0.5 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Schistosoma mansoni | FFA transport protein | 0.0224 | 0.9672 | 1 |
Trypanosoma brucei | acetyl-CoA synthetase, putative | 0.001 | 0 | 0.5 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.001 | 0 | 0.5 |
Trypanosoma brucei | long-chain-fatty-acid-CoA ligase, putative | 0.001 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.52 uM | Inhibition of mouse recombinant FATP1 acyl-coA synthetase activity using [14C]oleic acid as substrate | ChEMBL. | 22749869 |
IC50 (binding) | = 0.6 uM | Inhibition of human recombinant FATP1 acyl-coA synthetase activity using [14C]oleic acid as substrate | ChEMBL. | 22749869 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.