Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Protein K4 | 0.00266719 | 0.0688158 | 0.0688158 |
Loa Loa (eye worm) | phospholipase D | 0.00315729 | 0.100415 | 0.121269 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.00159986 | 0 | 0.5 |
Trypanosoma cruzi | cardiolipin synthetase, putative | 0.00582448 | 0.272382 | 1 |
Wolbachia endosymbiont of Brugia malayi | cardiolipin synthase | 0.00266719 | 0.0688158 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0144426 | 0.828033 | 1 |
Toxoplasma gondii | phospholipase D active site domain-containing protein | 0.00582448 | 0.272382 | 0.5 |
Trypanosoma brucei | phosphatidylglycerolphosphate synthase, mitochondrial | 0.00266719 | 0.0688158 | 0.252645 |
Chlamydia trachomatis | phospholipase D superfamily protein | 0.00266719 | 0.0688158 | 0.5 |
Trypanosoma cruzi | cardiolipin synthetase, putative | 0.00582448 | 0.272382 | 1 |
Plasmodium falciparum | mitochondrial cardiolipin synthase, putative | 0.00266719 | 0.0688158 | 0.5 |
Echinococcus granulosus | phospholipase D | 0.0152285 | 0.878708 | 0.865168 |
Chlamydia trachomatis | phospholipase D endonuclease family protein | 0.00266719 | 0.0688158 | 0.5 |
Chlamydia trachomatis | phospholipase D endonuclease family protein | 0.00266719 | 0.0688158 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0112853 | 0.624467 | 0.754157 |
Echinococcus multilocularis | phospholipase D | 0.0152285 | 0.878708 | 0.865168 |
Echinococcus granulosus | phospholipase D1 | 0.0171098 | 1 | 1 |
Entamoeba histolytica | phospholipase D, putative | 0.0171098 | 1 | 1 |
Echinococcus multilocularis | phospholipase D1 | 0.0171098 | 1 | 1 |
Trypanosoma brucei | cardiolipin synthetase | 0.00582448 | 0.272382 | 1 |
Brugia malayi | hypothetical protein | 0.00266719 | 0.0688158 | 0.0688158 |
Brugia malayi | Phospholipase D. Active site motif family protein | 0.00582448 | 0.272382 | 0.272382 |
Loa Loa (eye worm) | hypothetical protein | 0.0144426 | 0.828033 | 1 |
Trypanosoma brucei | cardiolipin synthetase, putative | 0.00582448 | 0.272382 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0112853 | 0.624467 | 0.754157 |
Brugia malayi | Phospholipase D. Active site motif family protein | 0.00315729 | 0.100415 | 0.100415 |
Loa Loa (eye worm) | hypothetical protein | 0.00315729 | 0.100415 | 0.121269 |
Chlamydia trachomatis | phospholipase D endonuclease family protein | 0.00266719 | 0.0688158 | 0.5 |
Chlamydia trachomatis | phospholipase D endonuclease family protein | 0.00266719 | 0.0688158 | 0.5 |
Brugia malayi | Phospholipase d protein 1 | 0.0171098 | 1 | 1 |
Plasmodium falciparum | phosphatidylglycerophosphate synthase | 0.00266719 | 0.0688158 | 0.5 |
Schistosoma mansoni | phospholipase D | 0.0171098 | 1 | 1 |
Chlamydia trachomatis | phospholipase D superfamily protein | 0.00266719 | 0.0688158 | 0.5 |
Plasmodium vivax | phosphatidylglycerophosphate synthase, putative | 0.00266719 | 0.0688158 | 0.5 |
Onchocerca volvulus | Putative phospholipase D | 0.00315729 | 0.100415 | 0.5 |
Leishmania major | cardiolipin synthetase, putative | 0.00266719 | 0.0688158 | 0.685313 |
Leishmania major | phosphatidylglycerophosphate synthase, putative | 0.00315729 | 0.100415 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00266719 | 0.0688158 | 0.0831075 |
Plasmodium vivax | cardiolipin synthetase, putative | 0.00266719 | 0.0688158 | 0.5 |
Entamoeba histolytica | phospholipase D, putative | 0.0171098 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.659 uM | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen C4 amastigotes | ChEMBL. | 22550999 |
IC50 (functional) | = 15.55 uM | Antileishmanial activity against Leishmania donovani MHOM-ET67/L82 amastigotes | ChEMBL. | 22550999 |
IC50 (functional) | = 27.51 uM | Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB 900 trypomastigotes | ChEMBL. | 22550999 |
Inhibition (binding) | Inhibition of Trypanosoma brucei brucei trypanothione reductase at <100 uM | ChEMBL. | 22550999 | |
Ratio IC50 (functional) | = 0.9 | Ratio of benznidazole IC50 to compound IC50 for Trypanosoma cruzi Tulahuen C4 amastigotes | ChEMBL. | 22550999 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma cruzi | ChEMBL23 | 22550999 | |
Leishmania donovani | ChEMBL23 | 22550999 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.