Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CAMK family protein kinase | 0.0166 | 0.3371 | 1 |
Entamoeba histolytica | protein kinase , putative | 0.0066 | 0 | 0.5 |
Trypanosoma brucei | aurora B kinase | 0.0066 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0364 | 1 | 1 |
Toxoplasma gondii | aurora kinase | 0.0066 | 0 | 0.5 |
Onchocerca volvulus | Dual specificity protein kinase TTK homolog | 0.0166 | 0.3371 | 0.5 |
Leishmania major | protein kinase, putative | 0.0066 | 0 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0166 | 0.3371 | 1 |
Schistosoma mansoni | dual specificity serine/threonine tyrosine kinase | 0.0166 | 0.3371 | 1 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0066 | 0 | 0.5 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0066 | 0 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0166 | 0.3371 | 0.3371 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0066 | 0 | 0.5 |
Loa Loa (eye worm) | TTK protein kinase | 0.0166 | 0.3371 | 0.3371 |
Entamoeba histolytica | protein kinase, putative | 0.0066 | 0 | 0.5 |
Echinococcus multilocularis | dual specificity serine:threonine tyrosine | 0.0166 | 0.3371 | 1 |
Giardia lamblia | Kinase, TTK | 0.0166 | 0.3371 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0066 | 0 | 0.5 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0066 | 0 | 0.5 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0066 | 0 | 0.5 |
Echinococcus granulosus | dual specificity serine:threonine tyrosine | 0.0166 | 0.3371 | 1 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0066 | 0 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0066 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 87.4 % | Inhibition of COX1 peroxidase activity assessed as formation of TMPD at 100 uM by colorimetric analysis | ChEMBL. | 22901385 |
Inhibition (binding) | = 88.95 % | Inhibition of COX2 peroxidase activity assessed as formation of TMPD at 100 uM by colorimetric analysis | ChEMBL. | 22901385 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.