Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | p21 protein (Cdc42/Rac)-activated kinase 4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | serine:threonine protein kinase PAK 4 | Get druggable targets OG5_131977 | All targets in OG5_131977 |
Loa Loa (eye worm) | STE/STE20/PAKB protein kinase | Get druggable targets OG5_131977 | All targets in OG5_131977 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 4 | Get druggable targets OG5_131977 | All targets in OG5_131977 |
Brugia malayi | serine/threonine-protein kinase PAK 7 | Get druggable targets OG5_131977 | All targets in OG5_131977 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0434 | 1 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase PAK 4 | 0.0202 | 0.4404 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0434 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.4885 | 0.0052 |
Entamoeba histolytica | protein kinase, putative | 0.0019 | 0 | 0.5 |
Trichomonas vaginalis | STE family protein kinase | 0.0019 | 0 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0019 | 0 | 0.5 |
Brugia malayi | serine/threonine-protein kinase PAK 7 | 0.0221 | 0.4858 | 0.4858 |
Schistosoma mansoni | protein kinase | 0.0019 | 0 | 0.5 |
Trichomonas vaginalis | STE family protein kinase | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | protein kinase | 0.0019 | 0 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0019 | 0 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0019 | 0 | 0.5 |
Giardia lamblia | Kinase, STE STE20 | 0.0019 | 0 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0434 | 1 | 0.5 |
Trichomonas vaginalis | STE family protein kinase | 0.0019 | 0 | 0.5 |
Trichomonas vaginalis | STE family protein kinase | 0.0019 | 0 | 0.5 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0434 | 1 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 4 | 0.0202 | 0.4404 | 1 |
Schistosoma mansoni | protein kinase | 0.0019 | 0 | 0.5 |
Entamoeba histolytica | p21-activated kinase | 0.0019 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 0.016 uM | Inhibition of PAK4-mediated GEF-H1 phosphorylation at Ser810 by cell based assay | ChEMBL. | 22554206 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.