Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase IV | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase VI | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carbonic anhydrase like protein 2 precursor | carbonic anhydrase II | 260 aa | 259 aa | 32.0 % |
Trypanosoma brucei | carbonic anhydrase-like protein | carbonic anhydrase VI | 308 aa | 280 aa | 27.9 % |
Trypanosoma brucei | carbonic anhydrase-like protein | carbonic anhydrase I | 261 aa | 281 aa | 25.3 % |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | carbonic anhydrase IV | 312 aa | 270 aa | 26.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0345 | 0.7202 | 0.7202 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0248 | 0.3886 | 0.5 |
Plasmodium falciparum | carbonic anhydrase | 0.0134 | 0 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0248 | 0.3886 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0427 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0248 | 0.3886 | 0.3886 |
Brugia malayi | carbohydrate phosphorylase | 0.0211 | 0.2631 | 0.2631 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0345 | 0.7202 | 0.7202 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0211 | 0.2631 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0248 | 0.3886 | 0.3886 |
Giardia lamblia | Glycogen phosphorylase | 0.0211 | 0.2631 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0248 | 0.3886 | 0.3886 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0211 | 0.2631 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0134 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0427 | 1 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0211 | 0.2631 | 0.2631 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0211 | 0.2631 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0248 | 0.3886 | 0.3886 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0345 | 0.7202 | 0.7202 |
Schistosoma mansoni | glycogen phosphorylase | 0.0211 | 0.2631 | 0.2631 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0211 | 0.2631 | 0.2631 |
Loa Loa (eye worm) | hypothetical protein | 0.0427 | 1 | 1 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0211 | 0.2631 | 0.2631 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0211 | 0.2631 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0427 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0427 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0248 | 0.3886 | 0.3886 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0248 | 0.3886 | 0.3886 |
Echinococcus multilocularis | acetylcholinesterase | 0.0427 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0427 | 1 | 1 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0211 | 0.2631 | 0.2631 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0345 | 0.7202 | 0.7202 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0211 | 0.2631 | 0.2631 |
Echinococcus granulosus | carbonic anhydrase II | 0.0248 | 0.3886 | 0.3886 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0248 | 0.3886 | 0.3886 |
Echinococcus granulosus | glycogen phosphorylase | 0.0211 | 0.2631 | 0.2631 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0248 | 0.3886 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0211 | 0.2631 | 0.5 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0211 | 0.2631 | 0.2631 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0345 | 0.7202 | 0.7202 |
Echinococcus granulosus | glycogen phosphorylase | 0.0211 | 0.2631 | 0.2631 |
Loa Loa (eye worm) | carboxylesterase | 0.0427 | 1 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.0248 | 0.3886 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0427 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0427 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0427 | 1 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0211 | 0.2631 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0427 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.39 uM | Inhibition of human carbonic anhydrase 2 esterase activity using 4-nitrophenylacetate as substrate | ChEMBL. | 22230050 |
Ki (binding) | = 0.47 uM | Inhibition of human carbonic anhydrase 6 esterase activity using 4-nitrophenylacetate as substrate | ChEMBL. | 22230050 |
Ki (binding) | = 0.88 uM | Inhibition of human carbonic anhydrase 4 esterase activity using 4-nitrophenylacetate as substrate | ChEMBL. | 22230050 |
Ki (binding) | = 1.1 uM | Inhibition of human carbonic anhydrase 1 esterase activity using 4-nitrophenylacetate as substrate | ChEMBL. | 22230050 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.