Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | histone deacetylase 1 | 0.0075 | 0.2274 | 0.3561 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0075 | 0.2274 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.6386 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.6386 | 1 |
Schistosoma mansoni | lipoxygenase | 0.018 | 0.6718 | 0.6718 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.6386 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.6386 | 1 |
Echinococcus granulosus | nuclear receptor co repressor related ncor | 0.0162 | 0.5978 | 0.5978 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0043 | 0.0916 | 0.0916 |
Entamoeba histolytica | histone deacetylase, putative | 0.0075 | 0.2274 | 0.5 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0075 | 0.2274 | 0.3561 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0043 | 0.0916 | 0.0916 |
Schistosoma mansoni | peroxidasin | 0.0172 | 0.6386 | 0.6386 |
Brugia malayi | Animal haem peroxidase family protein | 0.0172 | 0.6386 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.2274 | 0.3561 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.6386 | 1 |
Onchocerca volvulus | 0.0172 | 0.6386 | 1 | |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0043 | 0.0916 | 0.0916 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.6386 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0075 | 0.2274 | 0.5 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0043 | 0.0916 | 0.0916 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0172 | 0.6386 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.6386 | 1 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0075 | 0.2274 | 0.3561 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0916 | 0.1434 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0172 | 0.6386 | 1 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0075 | 0.2274 | 1 |
Loa Loa (eye worm) | doublecortin family protein | 0.0043 | 0.0916 | 0.1434 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0075 | 0.2274 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0916 | 0.1434 |
Onchocerca volvulus | Peroxidasin homolog | 0.0172 | 0.6386 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0075 | 0.2274 | 0.5 |
Brugia malayi | Peroxidasin | 0.0172 | 0.6386 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.6386 | 1 |
Schistosoma mansoni | histone deacetylase | 0.0075 | 0.2274 | 0.2274 |
Echinococcus granulosus | RUN | 0.0043 | 0.0916 | 0.0916 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0075 | 0.2274 | 0.5 |
Onchocerca volvulus | 0.0043 | 0.0916 | 0.1434 | |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.6386 | 1 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0075 | 0.2274 | 0.3561 |
Plasmodium falciparum | histone deacetylase 1 | 0.0075 | 0.2274 | 1 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0043 | 0.0916 | 0.0916 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.6386 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0257 | 1 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0075 | 0.2274 | 1 |
Brugia malayi | hypothetical protein | 0.0043 | 0.0916 | 0.1434 |
Trypanosoma brucei | histone deacetylase 1 | 0.0075 | 0.2274 | 1 |
Schistosoma mansoni | rab6-interacting | 0.0043 | 0.0916 | 0.0916 |
Echinococcus granulosus | histone deacetylase 1 | 0.0075 | 0.2274 | 0.2274 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0172 | 0.6386 | 1 |
Echinococcus multilocularis | RUN | 0.0043 | 0.0916 | 0.0916 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0075 | 0.2274 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0172 | 0.6386 | 1 |
Echinococcus granulosus | histone deacetylase 3 | 0.0075 | 0.2274 | 0.2274 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0172 | 0.6386 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0172 | 0.6386 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0172 | 0.6386 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0172 | 0.6386 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0075 | 0.2274 | 0.5 |
Leishmania major | histone deacetylase, putative | 0.0075 | 0.2274 | 1 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0043 | 0.0916 | 0.0916 |
Onchocerca volvulus | 0.0172 | 0.6386 | 1 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0172 | 0.6386 | 1 |
Brugia malayi | Histone deacetylase 1 | 0.0075 | 0.2274 | 0.3561 |
Echinococcus multilocularis | peroxidasin | 0.0172 | 0.6386 | 0.6386 |
Schistosoma mansoni | lipoxygenase | 0.0257 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0172 | 0.6386 | 0.6386 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0075 | 0.2274 | 0.5 |
Onchocerca volvulus | 0.0172 | 0.6386 | 1 | |
Echinococcus multilocularis | histone deacetylase 3 | 0.0075 | 0.2274 | 0.2274 |
Brugia malayi | Animal haem peroxidase family protein | 0.0172 | 0.6386 | 1 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0043 | 0.0916 | 0.4027 |
Schistosoma mansoni | rab6-interacting | 0.0043 | 0.0916 | 0.0916 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0916 | 0.0916 |
Schistosoma mansoni | loxhd1 | 0.0043 | 0.0916 | 0.0916 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0075 | 0.2274 | 0.2274 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0075 | 0.2274 | 0.5 |
Echinococcus multilocularis | nuclear receptor co repressor related (ncor) | 0.0162 | 0.5978 | 0.5978 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.6386 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.6386 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0172 | 0.6386 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0075 | 0.2274 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0172 | 0.6386 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0172 | 0.6386 | 1 |
Onchocerca volvulus | 0.0043 | 0.0916 | 0.1434 | |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.6386 | 1 |
Brugia malayi | hypothetical protein | 0.0043 | 0.0916 | 0.1434 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0075 | 0.2274 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0172 | 0.6386 | 1 |
Echinococcus granulosus | peroxidasin | 0.0172 | 0.6386 | 0.6386 |
Brugia malayi | Doublecortin family protein | 0.0043 | 0.0916 | 0.1434 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.6386 | 1 |
Brugia malayi | hypothetical protein | 0.0172 | 0.6386 | 1 |
Schistosoma mansoni | polycystin 1-related | 0.0043 | 0.0916 | 0.0916 |
Brugia malayi | Animal haem peroxidase family protein | 0.0172 | 0.6386 | 1 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0075 | 0.2274 | 1 |
Giardia lamblia | Histone deacetylase | 0.0075 | 0.2274 | 0.5 |
Leishmania major | histone deacetylase, putative | 0.0075 | 0.2274 | 1 |
Schistosoma mansoni | histone deacetylase | 0.0075 | 0.2274 | 0.2274 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0043 | 0.0916 | 0.4027 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | > 50 ug ml-1 | In vitro antimalarial activity of the compound against P. falciparum (NF-54) | ChEMBL. | 12161115 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.