Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | fatty acid desaturase, putative | 0.0183 | 1 | 0.5 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0169 | 0 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0183 | 1 | 1 |
Leishmania major | fatty-acid desaturase, putative | 0.0183 | 1 | 0.5 |
Onchocerca volvulus | 0.0183 | 1 | 0.5 | |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0169 | 0 | 0.5 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0169 | 0 | 0.5 |
Brugia malayi | acyl-CoA desaturase | 0.0169 | 0 | 0.5 |
Onchocerca volvulus | 0.0183 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 500 uM | Inhibition of human factor 10a using chromogenic spectrozyme F10a as substrate after 10 mins by spectrophotometry | ChEMBL. | 22770607 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.