Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Human immunodeficiency virus type 1 reverse transcriptase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Trypanosoma congolense | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Schistosoma mansoni | hypothetical protein | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Plasmodium yoelii | integrase-related | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma brucei | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.9248 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0095 | 0.9248 | 0.5 |
Onchocerca volvulus | 0.0095 | 0.9248 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.9248 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.9248 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0095 | 0.9248 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0095 | 0.9248 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.9248 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0095 | 0.9248 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.9248 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0095 | 0.9248 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0095 | 0.9248 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0095 | 0.9248 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.9248 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.9248 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0095 | 0.9248 | 0.5 |
Brugia malayi | Peroxidasin | 0.0095 | 0.9248 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0095 | 0.9248 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0095 | 0.9248 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.9248 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0095 | 0.9248 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0095 | 0.9248 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0095 | 0.9248 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.9248 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0095 | 0.9248 | 0.5 |
Onchocerca volvulus | 0.0095 | 0.9248 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0095 | 0.9248 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.9248 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.9248 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.9248 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.9248 | 0.5 |
Trypanosoma brucei | RNA helicase, putative | 0.01 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0095 | 0.9248 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.9248 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0095 | 0.9248 | 0.5 |
Onchocerca volvulus | 0.0095 | 0.9248 | 0.5 | |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0095 | 0.9248 | 0.5 |
Brugia malayi | hypothetical protein | 0.0095 | 0.9248 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0095 | 0.9248 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 0.08 uM | Inhibitory activity against human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) | ChEMBL. | 12086483 |
Activity (binding) | = 0.08 uM | Inhibitory activity against human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) | ChEMBL. | 12086483 |
ED50 (functional) | = 0.08 uM | Tested for the inhibition of wild type HIV-1 (IIIB) replication in MT-4 cells | ChEMBL. | 8863804 |
ED50 (functional) | = 0.08 uM | Tested for the inhibition of wild type HIV-1 (IIIB) replication in MT-4 cells | ChEMBL. | 8863804 |
ED50 (functional) | = 0.3 uM | Inhibition of mutant type (Cys181) HIV-1 (IIIB) replication in MT-4 cells | ChEMBL. | 8863804 |
ED50 (functional) | = 0.3 uM | Inhibition of mutant type (Cys181) HIV-1 (IIIB) replication in MT-4 cells | ChEMBL. | 8863804 |
ED50 (functional) | > 2 uM | Inhibition of mutant type (Ile100) HIV-1 (IIIB) replication in MT-4 cells | ChEMBL. | 8863804 |
ED50 (functional) | > 2 uM | Inhibition of mutant type (Ile100) HIV-1 (IIIB) replication in MT-4 cells | ChEMBL. | 8863804 |
IC50 (binding) | = 0.023 uM | Tested for the inhibition of wild type HIV-1 (IIIB) RT | ChEMBL. | 8863804 |
IC50 (binding) | = 0.023 uM | Tested for the inhibition of wild type HIV-1 (IIIB) RT | ChEMBL. | 8863804 |
IC50 (binding) | > 2 uM | Tested for the inhibition of mutant type (Ile100) HIV-1 (IIIB) RT | ChEMBL. | 8863804 |
IC50 (binding) | > 2 uM | Tested for the inhibition of mutant type (Cys181) HIV-1 (IIIB) RT | ChEMBL. | 8863804 |
IC50 (binding) | > 2 uM | Tested for the inhibition of mutant type (Ile100) HIV-1 (IIIB) RT | ChEMBL. | 8863804 |
IC50 (binding) | > 2 uM | Tested for the inhibition of mutant type (Cys181) HIV-1 (IIIB) RT | ChEMBL. | 8863804 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.