Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor XIII, A1 polypeptide | Starlite/ChEMBL | References |
Homo sapiens | transglutaminase 2 | Starlite/ChEMBL | References |
Homo sapiens | transglutaminase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Onchocerca volvulus | Get druggable targets OG5_131468 | All targets in OG5_131468 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | transglutaminase family protein | 0.0129 | 0.3205 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0129 | 0.3205 | 0.5 |
Echinococcus granulosus | geminin | 0.0191 | 0.5178 | 1 |
Echinococcus multilocularis | geminin | 0.0191 | 0.5178 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0135 | 0.3381 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0 | 0.5 |
Mycobacterium ulcerans | putative transglutaminase-like protein | 0.0129 | 0.3205 | 0.5 |
Giardia lamblia | Transglutaminase/protease, putative | 0.0129 | 0.3205 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0129 | 0.3205 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0129 | 0.3205 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0129 | 0.3205 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0129 | 0.3205 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0028 | 0 | 0.5 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0129 | 0.3205 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0135 | 0.3381 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0135 | 0.3381 | 1 |
Trichomonas vaginalis | peptide N-glycanase, putative | 0.0129 | 0.3205 | 0.5 |
Mycobacterium tuberculosis | Long conserved protein | 0.0129 | 0.3205 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0129 | 0.3205 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.5178 | 1 |
Giardia lamblia | Hypothetical protein | 0.0129 | 0.3205 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.5178 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0 | 0.5 |
Brugia malayi | Thioredoxin family protein | 0.0129 | 0.3205 | 0.9479 |
Mycobacterium tuberculosis | Conserved protein | 0.0129 | 0.3205 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.041 uM | Inhibition of human recombinant TG2 by fluorescent transamidation assay | ChEMBL. | 22224594 |
IC50 (binding) | = 0.31 uM | Inhibition of thrombin activated human F13a by fluorescent transamidation assay | ChEMBL. | 22224594 |
IC50 (binding) | = 0.81 uM | Inhibition of human TG2 in HEK cells by fluorescent transamidation assay | ChEMBL. | 22224594 |
IC50 (binding) | = 5.4 uM | Inhibition of human recombinant TG1 by fluorescent transamidation assay | ChEMBL. | 22224594 |
IC50 (binding) | > 80 uM | Inhibition of thrombin activated human TG3 by fluorescent transamidation assay | ChEMBL. | 22224594 |
Ratio IC50 (binding) | = 20 | Ratio of IC50 to human TG2 in HEK cells to IC50 for human recombinant TG2 | ChEMBL. | 22224594 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.