Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | HMG-CoA reductase | Starlite/ChEMBL | References |
Homo sapiens | 3-hydroxy-3-methylglutaryl-CoA reductase | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 100 nM | Inhibition of the incorporation of sodium [14C]-acetate into cholesterol in HEP G2 cells. | ChEMBL. | 1656041 |
IC50 (functional) | = 100 nM | Inhibition of the incorporation of sodium [14C]-acetate into cholesterol in HEP G2 cells. | ChEMBL. | 1656041 |
IC50 (binding) | = 400 nM | In vitro inhibition of HMG-CoA reductase in solubilized rat liver. | ChEMBL. | 1656041 |
IC50 (binding) | = 400 nM | In vitro inhibition of HMG-CoA reductase in solubilized rat liver. | ChEMBL. | 1656041 |
Relative potency (binding) | = 2 | Inhibition of HMG-CoA reductase compared to mevinolin. | ChEMBL. | 1656041 |
Relative potency (functional) | = 50 | Inhibition of HMG-CoA reductase compared to mevinolin. | ChEMBL. | 1656041 |
Relative potency (binding) | = 2 | Inhibition of HMG-CoA reductase compared to mevinolin. | ChEMBL. | 1656041 |
Relative potency (functional) | = 50 | Inhibition of HMG-CoA reductase compared to mevinolin. | ChEMBL. | 1656041 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.