Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein kinase C, theta | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132502 | All targets in OG5_132502 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132502 | All targets in OG5_132502 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132502 | All targets in OG5_132502 |
Onchocerca volvulus | Get druggable targets OG5_132502 | All targets in OG5_132502 | |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132502 | All targets in OG5_132502 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132502 | All targets in OG5_132502 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acylamino acid releasing enzyme | 0.0129 | 0.0666 | 0.0666 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0129 | 0.0666 | 0.5 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.1622 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0129 | 0.0666 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0545 | 0.3271 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.0961 | 0.0961 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.1622 | 1 | 1 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0545 | 0.3271 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0904 | 0.0904 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.1622 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.0666 | 0.0666 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0129 | 0.0666 | 0.0666 |
Echinococcus granulosus | prolyl endopeptidase | 0.0129 | 0.0666 | 0.0666 |
Trichomonas vaginalis | Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase | 0.0129 | 0.0666 | 0.5 |
Echinococcus granulosus | acylamino acid releasing enzyme | 0.0129 | 0.0666 | 0.0666 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0129 | 0.0666 | 0.5 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0129 | 0.0666 | 0.5 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0545 | 0.3271 | 0.3271 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0129 | 0.0666 | 0.5 |
Brugia malayi | hypothetical protein | 0.0417 | 0.2467 | 0.2467 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0129 | 0.0666 | 0.0666 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0129 | 0.0666 | 0.5 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0129 | 0.0666 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0904 | 0.0904 |
Onchocerca volvulus | 0.0167 | 0.0904 | 0.0256 | |
Loa Loa (eye worm) | hypothetical protein | 0.0417 | 0.2467 | 0.2467 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0129 | 0.0666 | 0.0666 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.0666 | 0.0666 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0545 | 0.3271 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.1622 | 1 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0129 | 0.0666 | 0.0666 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0545 | 0.3271 | 1 |
Plasmodium falciparum | peptidase, putative | 0.0129 | 0.0666 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0129 | 0.0666 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0904 | 0.0904 |
Mycobacterium tuberculosis | Probable peptidase | 0.0129 | 0.0666 | 0.5 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0129 | 0.0666 | 0.5 |
Schistosoma mansoni | acylaminoacyl-peptidase (S09 family) | 0.0129 | 0.0666 | 0.0666 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0129 | 0.0666 | 0.5 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0545 | 0.3271 | 0.3271 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.1622 | 1 | 1 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0545 | 0.3271 | 0.3271 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0129 | 0.0666 | 0.0666 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.0985 | 0.0985 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0545 | 0.3271 | 1 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0129 | 0.0666 | 0.5 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0545 | 0.3271 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.0666 | 0.0666 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0129 | 0.0666 | 0.0666 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0129 | 0.0666 | 0.0666 |
Mycobacterium tuberculosis | Probable protease II PtrBb [second part] (oligopeptidase B) | 0.0129 | 0.0666 | 0.5 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0545 | 0.3271 | 0.3271 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0129 | 0.0666 | 0.0666 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0129 | 0.0666 | 0.5 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0129 | 0.0666 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.038 uM | Inhibition of PKCtheta | ChEMBL. | 22738630 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.