Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | androgen receptor | Starlite/ChEMBL | No references |
Homo sapiens | cholesteryl ester transfer protein, plasma | Starlite/ChEMBL | References |
Homo sapiens | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | ankyrin 23/unc44 | 0.0017 | 0.0003 | 0.0001 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0832 | 0.2556 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0041 | 0.3255 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0832 | 0.2556 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0017 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0023 | 0.0832 | 0.2556 |
Echinococcus multilocularis | Ankyrin | 0.0018 | 0.0023 | 0.0021 |
Onchocerca volvulus | 0.0041 | 0.3255 | 1 | |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0017 | 0.0003 | 0.0008 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0003 | 0.0008 |
Onchocerca volvulus | 0.0041 | 0.3255 | 1 | |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0023 | 0.0832 | 0.2556 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0018 | 0.0023 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0832 | 0.2556 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0023 | 0.0832 | 0.2556 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0041 | 0.3255 | 1 |
Onchocerca volvulus | 0.0041 | 0.3255 | 1 | |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0023 | 0.0832 | 0.2556 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0041 | 0.3255 | 1 |
Echinococcus multilocularis | ankyrin repeat and death domain containing protein | 0.0017 | 0.0003 | 0.00000014065 |
Echinococcus granulosus | Ankyrin | 0.0018 | 0.0023 | 0.0021 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0832 | 0.2556 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.3255 | 1 |
Onchocerca volvulus | 0.0041 | 0.3255 | 1 | |
Onchocerca volvulus | 0.0041 | 0.3255 | 1 | |
Onchocerca volvulus | 0.0041 | 0.3255 | 1 | |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0089 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0017 | 0.0003 | 0.0008 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0023 | 0.0071 |
Echinococcus granulosus | ankyrin repeat and death domain containing protein | 0.0017 | 0.0003 | 0.00000014065 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0023 | 0.0832 | 0.2556 |
Onchocerca volvulus | 0.0023 | 0.0832 | 0.2556 | |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0832 | 0.2556 |
Brugia malayi | hypothetical protein | 0.0023 | 0.0832 | 0.2556 |
Brugia malayi | Uncoordinated protein 44 | 0.0017 | 0.0003 | 0.0008 |
Onchocerca volvulus | 0.0041 | 0.3255 | 1 | |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0017 | 0.0003 | 0.0008 |
Onchocerca volvulus | 0.0041 | 0.3255 | 1 | |
Brugia malayi | Death domain containing protein | 0.0017 | 0.0003 | 0.0008 |
Onchocerca volvulus | Netrin receptor homolog | 0.0017 | 0.0003 | 0.0008 |
Onchocerca volvulus | 0.0023 | 0.0832 | 0.2556 | |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0023 | 0.0832 | 0.2556 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0041 | 0.3255 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 57 nM | Inhibition of CETP in human plasma assessed as transfer of fluorescently labelled cholesteryl ester to VLDL by fluorimetry | ChEMBL. | 22543028 |
Potency (functional) | 4.3277 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.4845 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the NFkB signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.