Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | Silent information regulator 2 related protein 1 | 0.0119 | 0.5 | 0.5 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0119 | 0.5 | 0.5 |
Loa Loa (eye worm) | transcriptional regulator | 0.0119 | 0.5 | 0.5 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0119 | 0.5 | 0.5 |
Echinococcus multilocularis | chromatin regulatory protein sir2 | 0.0119 | 0.5 | 0.5 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.0119 | 0.5 | 0.5 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0119 | 0.5 | 0.5 |
Trypanosoma cruzi | Silent information regulator 2 related protein 1 | 0.0119 | 0.5 | 0.5 |
Echinococcus granulosus | NAD dependent deacetylase sirtuin 3 | 0.0119 | 0.5 | 0.5 |
Trypanosoma cruzi | Silent information regulator 2 related protein 1 | 0.0119 | 0.5 | 0.5 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0119 | 0.5 | 0.5 |
Echinococcus granulosus | chromatin regulatory protein sir2 | 0.0119 | 0.5 | 0.5 |
Leishmania major | silent information regulator 2, putative | 0.0119 | 0.5 | 0.5 |
Echinococcus multilocularis | NAD dependent deacetylase sirtuin 3 | 0.0119 | 0.5 | 0.5 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.0119 | 0.5 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0119 | 0.5 | 0.5 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0119 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.789 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.263 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.119 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.