Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.8756 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0067 | 0.3423 | 0.3909 |
Brugia malayi | Muscleblind-like protein | 0.0157 | 0.8756 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3423 | 0.3423 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3423 | 0.3423 |
Loa Loa (eye worm) | RNA binding protein | 0.0067 | 0.3423 | 0.3909 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3423 | 0.3423 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.8756 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0067 | 0.3423 | 0.3423 |
Brugia malayi | RNA binding protein | 0.0067 | 0.3423 | 0.3909 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0067 | 0.3423 | 0.3909 |
Echinococcus granulosus | muscleblind protein | 0.0157 | 0.8756 | 0.8756 |
Brugia malayi | TAR-binding protein | 0.0067 | 0.3423 | 0.3909 |
Brugia malayi | MH2 domain containing protein | 0.0125 | 0.6896 | 0.7876 |
Loa Loa (eye worm) | TAR-binding protein | 0.0067 | 0.3423 | 0.3909 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0125 | 0.6896 | 0.7876 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0125 | 0.6896 | 0.7876 |
Echinococcus multilocularis | muscleblind protein | 0.0157 | 0.8756 | 0.8756 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3423 | 0.3423 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0178 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0067 | 0.3423 | 0.3423 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3423 | 0.3423 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0157 | 0.8756 | 0.8756 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.262 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.