Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0139 | 0.0202 | 0.7862 | |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0075 | 0.002 | 0.0029 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0219 | 0.0426 | 0.2501 |
Loa Loa (eye worm) | hypothetical protein | 0.0204 | 0.0384 | 0.225 |
Echinococcus granulosus | roundabout 2 | 0.0089 | 0.006 | 0.0089 |
Loa Loa (eye worm) | hypothetical protein | 0.0672 | 0.1705 | 1 |
Schistosoma mansoni | cell adhesion molecule | 0.0075 | 0.002 | 0.004 |
Loa Loa (eye worm) | hypothetical protein | 0.0672 | 0.1705 | 1 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0204 | 0.0384 | 0.0784 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.006 | 0.0353 |
Echinococcus multilocularis | roundabout 2 | 0.0089 | 0.006 | 0.0089 |
Schistosoma mansoni | nephrin | 0.0071 | 0.0008 | 0.0017 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.002 | 0.0115 |
Schistosoma mansoni | hypothetical protein | 0.1802 | 0.4892 | 1 |
Echinococcus multilocularis | hedgehog | 0.2474 | 0.6787 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0204 | 0.0384 | 0.225 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0068 | 0 | 0.5 |
Echinococcus granulosus | twitchin | 0.0071 | 0.0008 | 0.0012 |
Brugia malayi | Hint module family protein | 0.0672 | 0.1705 | 0.1705 |
Schistosoma mansoni | intracisternal A-particle retropepsin (A02 family) | 0.1528 | 0.4118 | 0.8419 |
Echinococcus granulosus | Desert hedgehog protein | 0.2474 | 0.6787 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.006 | 0.0353 |
Brugia malayi | Hint module family protein | 0.0672 | 0.1705 | 0.1705 |
Echinococcus granulosus | neuroglian | 0.0071 | 0.0008 | 0.0012 |
Echinococcus multilocularis | serotonin receptor | 0.0204 | 0.0384 | 0.0565 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0159 | 0.0257 | 1 |
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.0278 | 0.0593 | 0.1212 |
Echinococcus multilocularis | serotonin receptor | 0.0204 | 0.0384 | 0.0565 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0219 | 0.0426 | 0.0426 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0204 | 0.0384 | 0.0565 |
Echinococcus multilocularis | neuroglian | 0.0071 | 0.0008 | 0.0012 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 38.6 nM | In vitro inhibition of HIV-1 protease | ChEMBL. | 7830273 |
Log IC50 (binding) | = 7.41 | Inhibitory activity against HIV-1 protease. | ChEMBL. | 9526559 |
Log IC50 (binding) | = 7.413 | Inhibitory activity against HIV-1 protease. | ChEMBL. | 10956210 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.