Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | deoxyuridine triphosphatase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium vivax | VIR protein | deoxyuridine triphosphatase | 252 aa | 229 aa | 18.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.006 | 0.1252 | 0.4682 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.004 | 0.0366 | 1 |
Onchocerca volvulus | 0.004 | 0.0366 | 0.5 | |
Entamoeba histolytica | hypothetical protein | 0.0091 | 0.2674 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.004 | 0.0366 | 1 |
Brugia malayi | dUTP diphosphatase | 0.0091 | 0.2674 | 1 |
Echinococcus granulosus | dUTP pyrophosphatase | 0.0091 | 0.2674 | 1 |
Toxoplasma gondii | deoxyuridine 5'-triphosphate nucleotidohydrolase, putative | 0.0091 | 0.2674 | 1 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.004 | 0.0366 | 0.0366 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative | 0.0091 | 0.2674 | 1 |
Onchocerca volvulus | 0.004 | 0.0366 | 0.5 | |
Trypanosoma brucei | hypothetical protein, conserved | 0.004 | 0.0366 | 0.5 |
Treponema pallidum | deoxyuridine 5'-triphosphate nucleotidohydrolase (dut) | 0.0091 | 0.2674 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.0366 | 0.0366 |
Mycobacterium ulcerans | beta-lactamase | 0.004 | 0.0366 | 1 |
Onchocerca volvulus | 0.004 | 0.0366 | 0.5 | |
Schistosoma mansoni | deoxyuridine 5'-triphosphate nucleotidohydrolase | 0.0091 | 0.2674 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.004 | 0.0366 | 1 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.004 | 0.0366 | 0.0366 |
Wolbachia endosymbiont of Brugia malayi | dUTPase | 0.0091 | 0.2674 | 1 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0091 | 0.2674 | 1 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0091 | 0.2674 | 1 |
Plasmodium vivax | deoxyuridine 5'-triphosphate nucleotidohydrolase, putative | 0.0091 | 0.2674 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.004 | 0.0366 | 1 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.004 | 0.0366 | 0.0366 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.004 | 0.0366 | 0.0366 |
Loa Loa (eye worm) | dUTP diphosphatase | 0.0091 | 0.2674 | 1 |
Leishmania major | hypothetical protein, conserved | 0.004 | 0.0366 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0091 | 0.2674 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.0366 | 0.0366 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0091 | 0.2674 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0366 | 0.5 |
Mycobacterium tuberculosis | Probable hydrolase | 0.004 | 0.0366 | 0.0366 |
Trichomonas vaginalis | deoxyuridine 5'-triphosphate nucleotidohydrolase, putative | 0.0091 | 0.2674 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0366 | 0.5 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.004 | 0.0366 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.004 | 0.0366 | 0.0366 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.004 | 0.0366 | 0.0366 |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.0366 | 0.0366 |
Entamoeba histolytica | hypothetical protein | 0.006 | 0.1252 | 0.4682 |
Plasmodium falciparum | deoxyuridine 5'-triphosphate nucleotidohydrolase | 0.0091 | 0.2674 | 0.5 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0091 | 0.2674 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.004 | 0.0366 | 1 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative | 0.0091 | 0.2674 | 1 |
Echinococcus multilocularis | dUTP pyrophosphatase | 0.0091 | 0.2674 | 1 |
Chlamydia trachomatis | deoxyuridine 5'-triphosphate nucleotidohydrolase | 0.0091 | 0.2674 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.17 uM | Inhibition of human dUTPase assessed as reduction in [5-3H]dUMP production incubated for 15 mins by HPLC | ChEMBL. | 22715973 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.