Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0298 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0298 | 0 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0298 | 0 | 0.5 |
Leishmania major | fatty-acid desaturase, putative | 0.132 | 0.405 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0298 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0298 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0298 | 0 | 0.5 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.1214 | 0.3629 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0298 | 0 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0298 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0298 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0298 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0298 | 0 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0298 | 0 | 0.5 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.1214 | 0.3629 | 0.3629 |
Schistosoma mansoni | nuclear hormone receptor | 0.0298 | 0 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0298 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0298 | 0 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0298 | 0 | 0.5 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.1214 | 0.3629 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0298 | 0 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.132 | 0.405 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0298 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0298 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0298 | 0 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0298 | 0 | 0.5 |
Onchocerca volvulus | 0.132 | 0.405 | 0.405 | |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0298 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0298 | 0 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0298 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0298 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.2822 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0298 | 0 | 0.5 |
Onchocerca volvulus | 0.132 | 0.405 | 0.405 | |
Trypanosoma brucei | fatty acid desaturase, putative | 0.132 | 0.405 | 0.5 |
Leishmania major | stearic acid desaturase, putative | 0.132 | 0.405 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2822 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0298 | 0 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0298 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0298 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0298 | 0 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0298 | 0 | 0.5 |
Brugia malayi | acyl-CoA desaturase | 0.1214 | 0.3629 | 0.3629 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
K app (binding) | = 0.014 uM | In vitro binding affinity of the compound against cortical muscarinic acetylcholine receptor measured by displacement of [3H]-OXO-M. | ChEMBL. | 1732546 |
K app (binding) | = 1.5 uM | In vitro binding affinity of the compound against cortical muscarinic acetylcholine receptor measured by displacement of [3H]-NMS. | ChEMBL. | 1732546 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.