Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sirtuin 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | transcriptional regulatory protein sir2a | sirtuin 2 | 234 aa | 207 aa | 26.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Histone deacetylase family protein | 0.0099 | 0.2082 | 0.063 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0135 | 0.3842 | 0.2713 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0099 | 0.2082 | 0.063 |
Echinococcus granulosus | histone deacetylase | 0.0099 | 0.2082 | 0.063 |
Trypanosoma cruzi | pyruvate dehydrogenase (lipoamide) kinase, putative | 0.0091 | 0.1696 | 0.0173 |
Trypanosoma cruzi | Silent information regulator 2 related protein 1 | 0.0135 | 0.3842 | 0.2713 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.026 | 1 | 1 |
Plasmodium falciparum | histone deacetylase, putative | 0.0099 | 0.2082 | 1 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0099 | 0.2082 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0099 | 0.2082 | 0.063 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.026 | 1 | 1 |
Leishmania major | developmentally regulated phosphoprotein-like protein | 0.026 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0099 | 0.2082 | 0.063 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.026 | 1 | 1 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0099 | 0.2082 | 0.063 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0105 | 0.2385 | 0.0988 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0135 | 0.3842 | 1 |
Echinococcus granulosus | histone deacetylase 7 | 0.0099 | 0.2082 | 0.063 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0099 | 0.2082 | 0.063 |
Loa Loa (eye worm) | histone deacetylase | 0.0099 | 0.2082 | 0.2082 |
Giardia lamblia | Hypothetical protein | 0.0135 | 0.3842 | 1 |
Loa Loa (eye worm) | transcriptional regulator | 0.0135 | 0.3842 | 0.3842 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0303 | 0.0303 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0135 | 0.3842 | 0.2713 |
Loa Loa (eye worm) | hypothetical protein | 0.026 | 1 | 1 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0099 | 0.2082 | 0.6211 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0099 | 0.2082 | 0.063 |
Brugia malayi | transcriptional regulator, Sir2 family protein | 0.0135 | 0.3842 | 0.2713 |
Trypanosoma brucei | Silent information regulator 2 related protein 1 | 0.0135 | 0.3842 | 0.2713 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0088 | 0.1549 | 0.1549 |
Echinococcus granulosus | histone deacetylase 6 | 0.0099 | 0.2082 | 0.063 |
Leishmania major | pyruvate dehydrogenase (lipoamide) kinase, putative | 0.0091 | 0.1696 | 0.0173 |
Echinococcus granulosus | histone deacetylase 6 | 0.0099 | 0.2082 | 0.063 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0135 | 0.3842 | 0.2713 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0105 | 0.2406 | 1 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0099 | 0.2082 | 0.063 |
Echinococcus multilocularis | histone deacetylase | 0.0099 | 0.2082 | 0.063 |
Trypanosoma brucei | histone deacetylase, putative | 0.0099 | 0.2082 | 0.063 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.0135 | 0.3842 | 0.8832 |
Trypanosoma brucei | developmentally regulated phosphoprotein | 0.026 | 1 | 1 |
Toxoplasma gondii | pyruvate dehydrogenase kinase, putative | 0.0091 | 0.1696 | 0.1711 |
Trypanosoma brucei | histone deacetylase 4 | 0.0099 | 0.2082 | 0.063 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0099 | 0.2082 | 0.2082 |
Echinococcus multilocularis | chromatin regulatory protein sir2 | 0.0135 | 0.3842 | 0.2713 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0088 | 0.1549 | 0.1549 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0099 | 0.2082 | 0.063 |
Leishmania major | histone deacetylase, putative | 0.0099 | 0.2082 | 0.063 |
Leishmania major | histone deacetylase, putative | 0.0099 | 0.2082 | 0.063 |
Echinococcus granulosus | Pyruvate dehydrogenase lipoamide kinase | 0.026 | 1 | 1 |
Trypanosoma cruzi | Silent information regulator 2 related protein 1 | 0.0135 | 0.3842 | 0.2713 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0105 | 0.2385 | 0.0988 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.0141 | 0.4145 | 1 |
Echinococcus granulosus | NAD dependent deacetylase sirtuin 3 | 0.0135 | 0.3842 | 0.2713 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.0245 | 0.929 | 0.916 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.0245 | 0.929 | 0.916 |
Trypanosoma cruzi | developmentally regulated phosphoprotein, putative | 0.026 | 1 | 1 |
Plasmodium vivax | histone deacetylase, putative | 0.0099 | 0.2082 | 1 |
Plasmodium falciparum | histone deacetylase 2 | 0.0099 | 0.2082 | 1 |
Trypanosoma brucei | histone deacetylase 3 | 0.0099 | 0.2082 | 0.063 |
Trypanosoma brucei | pyruvate dehydrogenase (lipoamide) kinase, putative | 0.0091 | 0.1696 | 0.0173 |
Echinococcus multilocularis | NAD dependent deacetylase sirtuin 3 | 0.0135 | 0.3842 | 0.2713 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0135 | 0.3842 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.1549 | 0.1549 |
Echinococcus granulosus | chromatin regulatory protein sir2 | 0.0135 | 0.3842 | 0.2713 |
Leishmania major | silent information regulator 2, putative | 0.0135 | 0.3842 | 0.2713 |
Echinococcus granulosus | histone deacetylase 6 | 0.0105 | 0.2385 | 0.0988 |
Brugia malayi | Histone deacetylase family protein | 0.0099 | 0.2082 | 0.063 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.5 uM | Inhibition of human recombinant GST-tagged SIRT2 preincubated for 5 mins measured after 1 hr by Fluor de Lys-based fluorescence assay | ChEMBL. | 22746324 |
IC50 (binding) | = 4.5 uM | Inhibition of recombinant GST-tagged sirtuin-2 (unknown origin) using KI179 as substrate after 1 hr by fluorescence assay | ChEMBL. | 25383691 |
Inhibition (binding) | < 10 % | Inhibition of recombinant GST-tagged SIRT1 preincubated at 200 uM for 5 mins measured after 1hr by Fluor de Lys-based fluorescence assay | ChEMBL. | 22746324 |
Inhibition (binding) | < 10 % | Inhibition of recombinant His-tagged SIRT3 preincubated at 200 uM for 5 mins measured after 1hr by Fluor de Lys-based fluorescence assay | ChEMBL. | 22746324 |
Inhibition (binding) | = 70 % | Inhibition of human recombinant GST-tagged SIRT2 preincubated at 200 uM for 5 mins measured after 1 hr by Fluor de Lys-based fluorescence assay | ChEMBL. | 22746324 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.