Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Animal haem peroxidase family protein | 0.0073 | 0.3395 | 0.3395 |
Brugia malayi | Hexokinase family protein | 0.0121 | 0.6021 | 0.6021 |
Loa Loa (eye worm) | hexokinase | 0.0192 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0101 | 0.4951 | 0.4951 |
Brugia malayi | Animal haem peroxidase family protein | 0.0073 | 0.3395 | 0.3395 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0039 | 0.0039 |
Echinococcus granulosus | hexokinase | 0.0192 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Brugia malayi | Animal haem peroxidase family protein | 0.0073 | 0.3395 | 0.3395 |
Trypanosoma brucei | hexokinase | 0.0192 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0192 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0073 | 0.3395 | 0.3395 |
Brugia malayi | Animal haem peroxidase family protein | 0.0073 | 0.3395 | 0.3395 |
Brugia malayi | Blistered cuticle protein 3 | 0.0073 | 0.3395 | 0.3395 |
Schistosoma mansoni | peroxidasin | 0.0073 | 0.3395 | 0.3395 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Trypanosoma brucei | hexokinase | 0.0192 | 1 | 0.5 |
Plasmodium vivax | hexokinase, putative | 0.0192 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Echinococcus granulosus | peroxidasin | 0.0073 | 0.3395 | 0.3395 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0073 | 0.3395 | 0.3395 |
Onchocerca volvulus | Dual oxidase homolog | 0.0073 | 0.3395 | 0.3395 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0073 | 0.3395 | 0.3395 |
Onchocerca volvulus | 0.0121 | 0.6021 | 0.6021 | |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.1734 | 0.1734 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0045 | 0.1795 | 0.1795 |
Brugia malayi | bZIP transcription factor family protein | 0.0101 | 0.4951 | 0.4951 |
Onchocerca volvulus | 0.0192 | 1 | 1 | |
Schistosoma mansoni | peroxidasin | 0.0073 | 0.3395 | 0.3395 |
Echinococcus multilocularis | peroxidasin | 0.0073 | 0.3395 | 0.3395 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.1734 | 0.1734 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0073 | 0.3395 | 0.3395 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.1632 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0192 | 1 | 1 |
Schistosoma mansoni | hexokinase | 0.0192 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.2022 | 0.2022 |
Echinococcus granulosus | voltage gated potassium channel | 0.0013 | 0.0039 | 0.0039 |
Brugia malayi | Hexokinase family protein | 0.0192 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0073 | 0.3395 | 0.3395 |
Brugia malayi | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Schistosoma mansoni | jun-related protein | 0.0082 | 0.3897 | 0.3897 |
Onchocerca volvulus | 0.0073 | 0.3395 | 0.3395 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0073 | 0.3395 | 0.3395 |
Loa Loa (eye worm) | hexokinase type II | 0.0192 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.1734 | 0.1734 |
Loa Loa (eye worm) | hexokinase | 0.0121 | 0.6021 | 0.6021 |
Echinococcus multilocularis | hexokinase | 0.0192 | 1 | 1 |
Echinococcus granulosus | jun protein | 0.0101 | 0.4951 | 0.4951 |
Onchocerca volvulus | Peroxidasin homolog | 0.0073 | 0.3395 | 0.3395 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Onchocerca volvulus | Peroxidase homolog | 0.0073 | 0.3395 | 0.3395 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0045 | 0.1795 | 0.1795 |
Treponema pallidum | hexokinase (hxk) | 0.0192 | 1 | 0.5 |
Brugia malayi | hexokinase type II | 0.0061 | 0.2717 | 0.2717 |
Onchocerca volvulus | Peroxidase homolog | 0.0073 | 0.3395 | 0.3395 |
Plasmodium falciparum | hexokinase | 0.0192 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0043 | 0.1734 | 0.1734 |
Echinococcus granulosus | hexokinase | 0.0192 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0045 | 0.1795 | 0.1795 |
Leishmania major | hexokinase, putative | 0.0192 | 1 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0013 | 0.0039 | 0.0039 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Echinococcus multilocularis | jun protein | 0.0101 | 0.4951 | 0.4951 |
Onchocerca volvulus | 0.008 | 0.3743 | 0.3743 | |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.2717 | 0.2717 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0039 | 0.0039 |
Entamoeba histolytica | hexokinase 1 | 0.0192 | 1 | 1 |
Toxoplasma gondii | hexokinase | 0.0192 | 1 | 0.5 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.1795 | 0.1795 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0101 | 0.4951 | 0.4951 |
Loa Loa (eye worm) | hexokinase | 0.006 | 0.2626 | 0.2626 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0039 | 0.0039 |
Brugia malayi | hypothetical protein | 0.008 | 0.3743 | 0.3743 |
Echinococcus multilocularis | hexokinase | 0.0192 | 1 | 1 |
Onchocerca volvulus | Hexokinase homolog | 0.0121 | 0.6021 | 0.6021 |
Onchocerca volvulus | 0.0192 | 1 | 1 | |
Loa Loa (eye worm) | hexokinase | 0.0192 | 1 | 1 |
Echinococcus multilocularis | hexokinase type 2 | 0.0192 | 1 | 1 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0013 | 0.0039 | 0.0039 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.3897 | 0.3897 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Onchocerca volvulus | Peroxidasin homolog | 0.0073 | 0.3395 | 0.3395 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.1632 | 0.5 |
Onchocerca volvulus | 0.0073 | 0.3395 | 0.3395 | |
Leishmania major | hexokinase, putative | 0.0192 | 1 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.1734 | 0.1734 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0013 | 0.0039 | 0.0039 |
Onchocerca volvulus | 0.0192 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1468 | 0.1468 |
Trypanosoma cruzi | hexokinase, putative | 0.0192 | 1 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0073 | 0.3395 | 0.3395 |
Trypanosoma cruzi | hexokinase, putative | 0.0192 | 1 | 0.5 |
Echinococcus granulosus | hexokinase type 2 | 0.0192 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.006 | 0.2626 | 0.2626 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.4797 | 0.4797 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.2717 | 0.2717 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.6605 | 0.6605 |
Brugia malayi | Peroxidasin | 0.0073 | 0.3395 | 0.3395 |
Onchocerca volvulus | 0.0073 | 0.3395 | 0.3395 | |
Entamoeba histolytica | hexokinase 2 | 0.0192 | 1 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0013 | 0.0039 | 0.0039 |
Trypanosoma brucei | hexokinase, putative | 0.0192 | 1 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.2022 | 0.2022 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Drug metabolism (ADMET) | = 0.9 % | Drug degradation in CD1 mouse liver microsomes assessed as formation of metabolite 4 at 20 uM after 30 mins by LCMS/MS analysis | ChEMBL. | 22809456 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.