Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Peroxidasin | 0.0073 | 0.3395 | 0.3395 |
Onchocerca volvulus | 0.0073 | 0.3395 | 0.3395 | |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.1734 | 0.1734 |
Loa Loa (eye worm) | hexokinase | 0.0192 | 1 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0073 | 0.3395 | 0.3395 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Onchocerca volvulus | 0.0192 | 1 | 1 | |
Onchocerca volvulus | Dual oxidase homolog | 0.0073 | 0.3395 | 0.3395 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0073 | 0.3395 | 0.3395 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Leishmania major | hexokinase, putative | 0.0192 | 1 | 0.5 |
Echinococcus granulosus | jun protein | 0.0101 | 0.4951 | 0.4951 |
Brugia malayi | Hexokinase family protein | 0.006 | 0.2626 | 0.2626 |
Trypanosoma brucei | hexokinase, putative | 0.0192 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.4797 | 0.4797 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Entamoeba histolytica | hexokinase 1 | 0.0192 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0121 | 0.6021 | 0.6021 |
Onchocerca volvulus | Hexokinase homolog | 0.0121 | 0.6021 | 0.6021 |
Schistosoma mansoni | hexokinase | 0.0192 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0073 | 0.3395 | 0.3395 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.3897 | 0.3897 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.1795 | 0.1795 |
Onchocerca volvulus | Peroxidase homolog | 0.0073 | 0.3395 | 0.3395 |
Loa Loa (eye worm) | hexokinase | 0.0192 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Schistosoma mansoni | jun-related protein | 0.0082 | 0.3897 | 0.3897 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0013 | 0.0039 | 0.0039 |
Brugia malayi | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Loa Loa (eye worm) | hexokinase type II | 0.0192 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0073 | 0.3395 | 0.3395 |
Brugia malayi | hypothetical protein | 0.0043 | 0.1734 | 0.1734 |
Entamoeba histolytica | hexokinase 2 | 0.0192 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Onchocerca volvulus | 0.0073 | 0.3395 | 0.3395 | |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0013 | 0.0039 | 0.0039 |
Echinococcus multilocularis | peroxidasin | 0.0073 | 0.3395 | 0.3395 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0101 | 0.4951 | 0.4951 |
Onchocerca volvulus | Peroxidase homolog | 0.0073 | 0.3395 | 0.3395 |
Echinococcus multilocularis | hexokinase type 2 | 0.0192 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.0192 | 1 | 1 |
Onchocerca volvulus | 0.0192 | 1 | 1 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0073 | 0.3395 | 0.3395 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Echinococcus granulosus | peroxidasin | 0.0073 | 0.3395 | 0.3395 |
Echinococcus multilocularis | hexokinase | 0.0192 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.008 | 0.3743 | 0.3743 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.2717 | 0.2717 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.1632 | 0.5 |
Onchocerca volvulus | 0.0121 | 0.6021 | 0.6021 | |
Onchocerca volvulus | 0.008 | 0.3743 | 0.3743 | |
Onchocerca volvulus | Peroxidasin homolog | 0.0073 | 0.3395 | 0.3395 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.1734 | 0.1734 |
Plasmodium vivax | hexokinase, putative | 0.0192 | 1 | 0.5 |
Treponema pallidum | hexokinase (hxk) | 0.0192 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.2717 | 0.2717 |
Brugia malayi | Hexokinase family protein | 0.0192 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0073 | 0.3395 | 0.3395 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0073 | 0.3395 | 0.3395 |
Trypanosoma brucei | hexokinase | 0.0192 | 1 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0073 | 0.3395 | 0.3395 |
Trypanosoma cruzi | hexokinase, putative | 0.0192 | 1 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0192 | 1 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.0192 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Echinococcus multilocularis | jun protein | 0.0101 | 0.4951 | 0.4951 |
Brugia malayi | bZIP transcription factor family protein | 0.0101 | 0.4951 | 0.4951 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Brugia malayi | Animal haem peroxidase family protein | 0.0073 | 0.3395 | 0.3395 |
Plasmodium falciparum | hexokinase | 0.0192 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.6605 | 0.6605 |
Echinococcus multilocularis | hexokinase | 0.0192 | 1 | 1 |
Echinococcus granulosus | voltage gated potassium channel | 0.0013 | 0.0039 | 0.0039 |
Schistosoma mansoni | peroxidasin | 0.0073 | 0.3395 | 0.3395 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0013 | 0.0039 | 0.0039 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0045 | 0.1795 | 0.1795 |
Loa Loa (eye worm) | hexokinase | 0.006 | 0.2626 | 0.2626 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0045 | 0.1795 | 0.1795 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0039 | 0.0039 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.1734 | 0.1734 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1468 | 0.1468 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0073 | 0.3395 | 0.3395 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0101 | 0.4951 | 0.4951 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0039 | 0.0039 |
Leishmania major | hexokinase, putative | 0.0192 | 1 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0045 | 0.1795 | 0.1795 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0039 | 0.0039 |
Brugia malayi | Animal haem peroxidase family protein | 0.0073 | 0.3395 | 0.3395 |
Onchocerca volvulus | 0.0073 | 0.3395 | 0.3395 | |
Echinococcus granulosus | hexokinase | 0.0192 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.0192 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.0192 | 1 | 1 |
Echinococcus granulosus | hexokinase type 2 | 0.0192 | 1 | 1 |
Toxoplasma gondii | hexokinase | 0.0192 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0013 | 0.0039 | 0.0039 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.2022 | 0.2022 |
Brugia malayi | Hexokinase family protein | 0.0121 | 0.6021 | 0.6021 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.2022 | 0.2022 |
Onchocerca volvulus | 0.0192 | 1 | 1 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0073 | 0.3395 | 0.3395 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Onchocerca volvulus | Peroxidasin homolog | 0.0073 | 0.3395 | 0.3395 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.1632 | 0.5 |
Brugia malayi | hexokinase type II | 0.0061 | 0.2717 | 0.2717 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.1734 | 0.1734 |
Brugia malayi | Animal haem peroxidase family protein | 0.0073 | 0.3395 | 0.3395 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 5 uM | Activation of human recombinant glucokinase assessed as concentration required for 1.5 fold increase in enzymatic activity | ChEMBL. | 22809456 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.