Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | AT19640p | 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled | 390 aa | 335 aa | 21.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0362 | 0.9868 | 0.9868 |
Onchocerca volvulus | Peroxidasin homolog | 0.0362 | 0.9868 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0362 | 0.9868 | 0.9868 |
Loa Loa (eye worm) | hypothetical protein | 0.0366 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0362 | 0.9868 | 0.9868 |
Brugia malayi | hypothetical protein | 0.0362 | 0.9868 | 0.9868 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0366 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0362 | 0.9868 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0362 | 0.9868 | 0.9868 |
Brugia malayi | thymidylate synthase | 0.013 | 0.1777 | 0.1777 |
Mycobacterium ulcerans | thymidylate synthase | 0.013 | 0.1777 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0118 | 0.1363 | 0.1363 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.3621 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0362 | 0.9868 | 0.9868 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.268 | 0.268 |
Schistosoma mansoni | peroxidasin | 0.0362 | 0.9868 | 0.9868 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.268 | 0.268 |
Brugia malayi | Animal haem peroxidase family protein | 0.0362 | 0.9868 | 0.9868 |
Loa Loa (eye worm) | hypothetical protein | 0.0362 | 0.9868 | 0.9868 |
Loa Loa (eye worm) | thymidylate synthase | 0.013 | 0.1777 | 0.1777 |
Brugia malayi | Peroxidasin | 0.0362 | 0.9868 | 0.9868 |
Onchocerca volvulus | Peroxidasin homolog | 0.0362 | 0.9868 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0118 | 0.1363 | 0.1382 |
Loa Loa (eye worm) | hypothetical protein | 0.0362 | 0.9868 | 0.9868 |
Loa Loa (eye worm) | hypothetical protein | 0.0362 | 0.9868 | 0.9868 |
Loa Loa (eye worm) | hypothetical protein | 0.0362 | 0.9868 | 0.9868 |
Onchocerca volvulus | 0.0362 | 0.9868 | 1 | |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0156 | 0.268 | 0.268 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0118 | 0.1363 | 0.1382 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.3621 | 0.5 |
Giardia lamblia | High cysteine protein | 0.0079 | 0 | 0.5 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0156 | 0.268 | 0.2716 |
Onchocerca volvulus | 0.013 | 0.1777 | 0.1801 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0362 | 0.9868 | 0.9868 |
Schistosoma mansoni | lipoxygenase | 0.0082 | 0.0127 | 0.0127 |
Brugia malayi | Animal haem peroxidase family protein | 0.0362 | 0.9868 | 0.9868 |
Loa Loa (eye worm) | hypothetical protein | 0.0366 | 1 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0362 | 0.9868 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0362 | 0.9868 | 0.9868 |
Loa Loa (eye worm) | hypothetical protein | 0.0362 | 0.9868 | 0.9868 |
Brugia malayi | Animal haem peroxidase family protein | 0.0362 | 0.9868 | 0.9868 |
Loa Loa (eye worm) | hypothetical protein | 0.0362 | 0.9868 | 0.9868 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.3621 | 0.5 |
Echinococcus multilocularis | serotonin receptor | 0.0156 | 0.268 | 0.2716 |
Onchocerca volvulus | Peroxidase homolog | 0.0362 | 0.9868 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0362 | 0.9868 | 0.9868 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0183 | 0.3621 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0362 | 0.9868 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.013 | 0.1777 | 0.1801 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0362 | 0.9868 | 0.9868 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0362 | 0.9868 | 0.9868 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.013 | 0.1777 | 0.1777 |
Onchocerca volvulus | 0.0362 | 0.9868 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0362 | 0.9868 | 0.9868 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.3621 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.013 | 0.1777 | 0.1801 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0362 | 0.9868 | 0.9868 |
Brugia malayi | Blistered cuticle protein 3 | 0.0362 | 0.9868 | 0.9868 |
Onchocerca volvulus | 0.0362 | 0.9868 | 1 | |
Schistosoma mansoni | peroxidasin | 0.0362 | 0.9868 | 0.9868 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.013 | 0.1777 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0321 | 0.8445 | 0.8445 |
Echinococcus multilocularis | serotonin receptor | 0.0156 | 0.268 | 0.2716 |
Onchocerca volvulus | Dual oxidase homolog | 0.0362 | 0.9868 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0362 | 0.9868 | 0.9868 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.3621 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.013 | 0.1777 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0362 | 0.9868 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0362 | 0.9868 | 0.9868 |
Loa Loa (eye worm) | hypothetical protein | 0.0362 | 0.9868 | 0.9868 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 2.3 | Intrinsic activity of the compound for Antagonism of 5-hydroxytryptamine 1B receptor-mediated stimulation of [35S]-GTP gamma S binding | ChEMBL. | 9357521 |
Ki (binding) | = 6.1 nM | Binding affinity of the compound for 5-hydroxytryptamine 1B receptor in C6-glial transfected cell type using [3H]-GR-125,743 as radioligand | ChEMBL. | 9357521 |
Ki (binding) | = 19 nM | Binding affinity of the compound for 5-hydroxytryptamine 1B receptor in C6-glial transfected cell type using [3H]-5-CT as radioligand | ChEMBL. | 9357521 |
Ki (binding) | = 169 nM | Binding affinity of the compound for 5-hydroxytryptamine 1D receptor in Cos-7 transfected cell type using [3H]-5-CT as radioligand | ChEMBL. | 9357521 |
Ki (binding) | = 633 nM | Binding affinity of the compound for 5-hydroxytryptamine 1A receptor in HeLa transfected cell type using [3H]-8-OH-DPAT as radioligand | ChEMBL. | 9357521 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.