Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.2022 | 0.2022 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.2022 | 0.2022 |
Brugia malayi | Hexokinase family protein | 0.0121 | 0.6021 | 0.6021 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0013 | 0.0039 | 0.0039 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Onchocerca volvulus | Peroxidasin homolog | 0.0073 | 0.3395 | 0.3395 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0073 | 0.3395 | 0.3395 |
Onchocerca volvulus | 0.0192 | 1 | 1 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0073 | 0.3395 | 0.3395 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.1734 | 0.1734 |
Brugia malayi | hexokinase type II | 0.0061 | 0.2717 | 0.2717 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.1632 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0039 | 0.0039 |
Leishmania major | hexokinase, putative | 0.0192 | 1 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0101 | 0.4951 | 0.4951 |
Brugia malayi | Animal haem peroxidase family protein | 0.0073 | 0.3395 | 0.3395 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0039 | 0.0039 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0045 | 0.1795 | 0.1795 |
Onchocerca volvulus | 0.0073 | 0.3395 | 0.3395 | |
Toxoplasma gondii | hexokinase | 0.0192 | 1 | 0.5 |
Echinococcus granulosus | hexokinase type 2 | 0.0192 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.0192 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.0192 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.0192 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.0192 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.6605 | 0.6605 |
Schistosoma mansoni | peroxidasin | 0.0073 | 0.3395 | 0.3395 |
Echinococcus granulosus | voltage gated potassium channel | 0.0013 | 0.0039 | 0.0039 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0045 | 0.1795 | 0.1795 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0039 | 0.0039 |
Loa Loa (eye worm) | hexokinase | 0.006 | 0.2626 | 0.2626 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0045 | 0.1795 | 0.1795 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0013 | 0.0039 | 0.0039 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0073 | 0.3395 | 0.3395 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1468 | 0.1468 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.1734 | 0.1734 |
Trypanosoma brucei | hexokinase | 0.0192 | 1 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0073 | 0.3395 | 0.3395 |
Schistosoma mansoni | peroxidasin | 0.0073 | 0.3395 | 0.3395 |
Trypanosoma brucei | hexokinase | 0.0192 | 1 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.0192 | 1 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0073 | 0.3395 | 0.3395 |
Brugia malayi | bZIP transcription factor family protein | 0.0101 | 0.4951 | 0.4951 |
Echinococcus multilocularis | jun protein | 0.0101 | 0.4951 | 0.4951 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Trypanosoma cruzi | hexokinase, putative | 0.0192 | 1 | 0.5 |
Plasmodium falciparum | hexokinase | 0.0192 | 1 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0073 | 0.3395 | 0.3395 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Brugia malayi | Animal haem peroxidase family protein | 0.0073 | 0.3395 | 0.3395 |
Onchocerca volvulus | 0.0192 | 1 | 1 | |
Echinococcus multilocularis | hexokinase | 0.0192 | 1 | 1 |
Echinococcus multilocularis | hexokinase type 2 | 0.0192 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.0192 | 1 | 1 |
Echinococcus granulosus | peroxidasin | 0.0073 | 0.3395 | 0.3395 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Onchocerca volvulus | Peroxidasin homolog | 0.0073 | 0.3395 | 0.3395 |
Onchocerca volvulus | 0.008 | 0.3743 | 0.3743 | |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.1632 | 0.5 |
Onchocerca volvulus | 0.0121 | 0.6021 | 0.6021 | |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.2717 | 0.2717 |
Brugia malayi | hypothetical protein | 0.008 | 0.3743 | 0.3743 |
Brugia malayi | Hexokinase family protein | 0.0192 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.2717 | 0.2717 |
Treponema pallidum | hexokinase (hxk) | 0.0192 | 1 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.1734 | 0.1734 |
Plasmodium vivax | hexokinase, putative | 0.0192 | 1 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0013 | 0.0039 | 0.0039 |
Schistosoma mansoni | jun-related protein | 0.0082 | 0.3897 | 0.3897 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Loa Loa (eye worm) | hexokinase type II | 0.0192 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0073 | 0.3395 | 0.3395 |
Brugia malayi | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Echinococcus multilocularis | peroxidasin | 0.0073 | 0.3395 | 0.3395 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0013 | 0.0039 | 0.0039 |
Onchocerca volvulus | 0.0073 | 0.3395 | 0.3395 | |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Entamoeba histolytica | hexokinase 2 | 0.0192 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0043 | 0.1734 | 0.1734 |
Onchocerca volvulus | Peroxidase homolog | 0.0073 | 0.3395 | 0.3395 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0101 | 0.4951 | 0.4951 |
Schistosoma mansoni | hexokinase | 0.0192 | 1 | 1 |
Onchocerca volvulus | Hexokinase homolog | 0.0121 | 0.6021 | 0.6021 |
Loa Loa (eye worm) | hexokinase | 0.0121 | 0.6021 | 0.6021 |
Onchocerca volvulus | Peroxidase homolog | 0.0073 | 0.3395 | 0.3395 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.1795 | 0.1795 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.3897 | 0.3897 |
Brugia malayi | Animal haem peroxidase family protein | 0.0073 | 0.3395 | 0.3395 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Loa Loa (eye worm) | hexokinase | 0.0192 | 1 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0073 | 0.3395 | 0.3395 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.1734 | 0.1734 |
Loa Loa (eye worm) | hexokinase | 0.0192 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Onchocerca volvulus | 0.0073 | 0.3395 | 0.3395 | |
Brugia malayi | Peroxidasin | 0.0073 | 0.3395 | 0.3395 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Leishmania major | hexokinase, putative | 0.0192 | 1 | 0.5 |
Echinococcus granulosus | jun protein | 0.0101 | 0.4951 | 0.4951 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0073 | 0.3395 | 0.3395 |
Onchocerca volvulus | Dual oxidase homolog | 0.0073 | 0.3395 | 0.3395 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Onchocerca volvulus | 0.0192 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Trypanosoma brucei | hexokinase, putative | 0.0192 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.4797 | 0.4797 |
Brugia malayi | Hexokinase family protein | 0.006 | 0.2626 | 0.2626 |
Entamoeba histolytica | hexokinase 1 | 0.0192 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 0.18 uM | Activation of human recombinant glucokinase assessed as concentration required for 1.5 fold increase in enzymatic activity | ChEMBL. | 22809456 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.