Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.2022 | 0.2022 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0013 | 0.0039 | 0.0039 |
Trypanosoma brucei | hexokinase, putative | 0.0192 | 1 | 0.5 |
Brugia malayi | Peroxidasin | 0.0073 | 0.3395 | 0.3395 |
Onchocerca volvulus | 0.0073 | 0.3395 | 0.3395 | |
Entamoeba histolytica | hexokinase 2 | 0.0192 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.6605 | 0.6605 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.2717 | 0.2717 |
Brugia malayi | Hexokinase family protein | 0.006 | 0.2626 | 0.2626 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.4797 | 0.4797 |
Echinococcus granulosus | hexokinase type 2 | 0.0192 | 1 | 1 |
Trypanosoma cruzi | hexokinase, putative | 0.0192 | 1 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0073 | 0.3395 | 0.3395 |
Trypanosoma cruzi | hexokinase, putative | 0.0192 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1468 | 0.1468 |
Onchocerca volvulus | 0.0192 | 1 | 1 | |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0013 | 0.0039 | 0.0039 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.1734 | 0.1734 |
Onchocerca volvulus | 0.0073 | 0.3395 | 0.3395 | |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.1632 | 0.5 |
Leishmania major | hexokinase, putative | 0.0192 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Onchocerca volvulus | Peroxidasin homolog | 0.0073 | 0.3395 | 0.3395 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.3897 | 0.3897 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0013 | 0.0039 | 0.0039 |
Echinococcus multilocularis | hexokinase type 2 | 0.0192 | 1 | 1 |
Onchocerca volvulus | 0.0192 | 1 | 1 | |
Loa Loa (eye worm) | hexokinase | 0.0192 | 1 | 1 |
Onchocerca volvulus | Hexokinase homolog | 0.0121 | 0.6021 | 0.6021 |
Echinococcus multilocularis | hexokinase | 0.0192 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.008 | 0.3743 | 0.3743 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0039 | 0.0039 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0101 | 0.4951 | 0.4951 |
Loa Loa (eye worm) | hexokinase | 0.006 | 0.2626 | 0.2626 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.1795 | 0.1795 |
Toxoplasma gondii | hexokinase | 0.0192 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 1 | 0.0192 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0039 | 0.0039 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.2717 | 0.2717 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Onchocerca volvulus | 0.008 | 0.3743 | 0.3743 | |
Echinococcus multilocularis | jun protein | 0.0101 | 0.4951 | 0.4951 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0013 | 0.0039 | 0.0039 |
Leishmania major | hexokinase, putative | 0.0192 | 1 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0045 | 0.1795 | 0.1795 |
Echinococcus granulosus | hexokinase | 0.0192 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0043 | 0.1734 | 0.1734 |
Plasmodium falciparum | hexokinase | 0.0192 | 1 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0073 | 0.3395 | 0.3395 |
Treponema pallidum | hexokinase (hxk) | 0.0192 | 1 | 0.5 |
Brugia malayi | hexokinase type II | 0.0061 | 0.2717 | 0.2717 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0045 | 0.1795 | 0.1795 |
Onchocerca volvulus | Peroxidase homolog | 0.0073 | 0.3395 | 0.3395 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Onchocerca volvulus | Peroxidasin homolog | 0.0073 | 0.3395 | 0.3395 |
Echinococcus granulosus | jun protein | 0.0101 | 0.4951 | 0.4951 |
Echinococcus multilocularis | hexokinase | 0.0192 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.1734 | 0.1734 |
Loa Loa (eye worm) | hexokinase | 0.0121 | 0.6021 | 0.6021 |
Loa Loa (eye worm) | hexokinase type II | 0.0192 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0073 | 0.3395 | 0.3395 |
Onchocerca volvulus | 0.0073 | 0.3395 | 0.3395 | |
Schistosoma mansoni | jun-related protein | 0.0082 | 0.3897 | 0.3897 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0073 | 0.3395 | 0.3395 |
Brugia malayi | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Echinococcus granulosus | voltage gated potassium channel | 0.0013 | 0.0039 | 0.0039 |
Brugia malayi | Hexokinase family protein | 0.0192 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.2022 | 0.2022 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Schistosoma mansoni | hexokinase | 0.0192 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.0192 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.1632 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0073 | 0.3395 | 0.3395 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.1734 | 0.1734 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Echinococcus multilocularis | peroxidasin | 0.0073 | 0.3395 | 0.3395 |
Schistosoma mansoni | peroxidasin | 0.0073 | 0.3395 | 0.3395 |
Onchocerca volvulus | 0.0192 | 1 | 1 | |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0045 | 0.1795 | 0.1795 |
Brugia malayi | bZIP transcription factor family protein | 0.0101 | 0.4951 | 0.4951 |
Onchocerca volvulus | 0.0121 | 0.6021 | 0.6021 | |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.1734 | 0.1734 |
Onchocerca volvulus | Dual oxidase homolog | 0.0073 | 0.3395 | 0.3395 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0073 | 0.3395 | 0.3395 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0073 | 0.3395 | 0.3395 |
Echinococcus granulosus | peroxidasin | 0.0073 | 0.3395 | 0.3395 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Plasmodium vivax | hexokinase, putative | 0.0192 | 1 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0192 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Schistosoma mansoni | peroxidasin | 0.0073 | 0.3395 | 0.3395 |
Brugia malayi | Blistered cuticle protein 3 | 0.0073 | 0.3395 | 0.3395 |
Brugia malayi | Animal haem peroxidase family protein | 0.0073 | 0.3395 | 0.3395 |
Brugia malayi | Animal haem peroxidase family protein | 0.0073 | 0.3395 | 0.3395 |
Echinococcus granulosus | hexokinase | 0.0192 | 1 | 1 |
Trypanosoma brucei | hexokinase | 0.0192 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Brugia malayi | Animal haem peroxidase family protein | 0.0073 | 0.3395 | 0.3395 |
Echinococcus granulosus | hexokinase | 0.0192 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0073 | 0.3395 | 0.3395 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0039 | 0.0039 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0101 | 0.4951 | 0.4951 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3395 | 0.3395 |
Loa Loa (eye worm) | hexokinase | 0.0192 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.0121 | 0.6021 | 0.6021 |
Brugia malayi | Animal haem peroxidase family protein | 0.0073 | 0.3395 | 0.3395 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 0.33 uM | Activation of human recombinant glucokinase assessed as concentration required for 1.5 fold increase in enzymatic activity | ChEMBL. | 22809456 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.