Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | lipase | 0.0147 | 0.6537 | 0.6537 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0147 | 0.6537 | 1 |
Onchocerca volvulus | 0.0147 | 0.6537 | 1 | |
Plasmodium vivax | diacylglycerol O-acyltransferase, putative | 0.0021 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0021 | 0 | 0.5 |
Plasmodium falciparum | diacylglycerol O-acyltransferase | 0.0021 | 0 | 0.5 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0147 | 0.6537 | 0.6537 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0147 | 0.6537 | 0.6537 |
Trypanosoma brucei | lipase domain protein, putative | 0.0147 | 0.6537 | 1 |
Brugia malayi | Lipase family protein | 0.0147 | 0.6537 | 1 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.0021 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 1 | 1 |
Toxoplasma gondii | acyl-CoA:diacylglycerol acyltransferase 1-related enzyme | 0.0021 | 0 | 0.5 |
Toxoplasma gondii | acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha | 0.0021 | 0 | 0.5 |
Treponema pallidum | alginate O-acetylation protein (algI) | 0.0021 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0147 | 0.6537 | 1 |
Entamoeba histolytica | vacuolar protein sorting 26 | 0.0021 | 0 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.0147 | 0.6537 | 1 |
Schistosoma mansoni | sterol O-acyltransferase 1 | 0.0214 | 1 | 1 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | sterol O acyltransferase 1 | 0.0214 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.8918 | 0.8918 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0147 | 0.6537 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0147 | 0.6537 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0021 | 0 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0147 | 0.6537 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.