Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | TetR family transcriptional regulator | 0.2684 | 1 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0052 | 0.0118 | 1 |
Mycobacterium ulcerans | AcrR family transcriptional regulator | 0.2684 | 1 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0035 | 0.0056 | 0.5392 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0118 | 1 |
Mycobacterium ulcerans | transcriptional regulator | 0.2684 | 1 | 0.5 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0052 | 0.0118 | 1 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0038 | 0.0067 | 0.8166 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0042 | 0.0081 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0048 | 0.0103 | 1 |
Mycobacterium tuberculosis | Transcriptional regulatory repressor protein (TetR-family) EthR | 0.2684 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.