Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0037 | 0.1018 | 1 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0037 | 0.1018 | 1 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0037 | 0.1018 | 1 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0037 | 0.1018 | 1 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0037 | 0.1018 | 1 |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0037 | 0.1018 | 1 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0037 | 0.1018 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0188 | 1 | 0.5 |
Onchocerca volvulus | 0.0037 | 0.1018 | 1 | |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0188 | 1 | 0.5 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0037 | 0.1018 | 1 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0037 | 0.1018 | 1 |
Loa Loa (eye worm) | ACC-1 protein | 0.0037 | 0.1018 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1018 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0188 | 1 | 0.5 |
Onchocerca volvulus | 0.0037 | 0.1018 | 1 | |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0037 | 0.1018 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0037 | 0.1018 | 1 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0037 | 0.1018 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1018 | 1 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0037 | 0.1018 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0037 | 0.1018 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0037 | 0.1018 | 1 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0037 | 0.1018 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0037 | 0.1018 | 1 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0037 | 0.1018 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1018 | 1 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0037 | 0.1018 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0188 | 1 | 0.5 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0037 | 0.1018 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0037 | 0.1018 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0037 | 0.1018 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0037 | 0.1018 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1018 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1018 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0037 | 0.1018 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1018 | 1 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0037 | 0.1018 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1018 | 1 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0037 | 0.1018 | 1 |
Echinococcus granulosus | nAChR subunit | 0.0037 | 0.1018 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1018 | 1 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0037 | 0.1018 | 1 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0037 | 0.1018 | 1 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0037 | 0.1018 | 1 |
Entamoeba histolytica | hypothetical protein | 0.002 | 0 | 0.5 |
Echinococcus multilocularis | nAChR subunit | 0.0037 | 0.1018 | 1 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0037 | 0.1018 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0037 | 0.1018 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0037 | 0.1018 | 1 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0037 | 0.1018 | 1 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0037 | 0.1018 | 1 |
Brugia malayi | Cation transporter family protein | 0.0037 | 0.1018 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0188 | 1 | 0.5 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0037 | 0.1018 | 1 |
Onchocerca volvulus | 0.0037 | 0.1018 | 1 | |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0037 | 0.1018 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1018 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0037 | 0.1018 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1018 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1018 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0188 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1018 | 1 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0037 | 0.1018 | 1 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0037 | 0.1018 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0037 | 0.1018 | 1 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0037 | 0.1018 | 1 |
Loa Loa (eye worm) | ACC-1 protein | 0.0037 | 0.1018 | 1 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0037 | 0.1018 | 1 |
Onchocerca volvulus | 0.0037 | 0.1018 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1018 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1018 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0037 | 0.1018 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1018 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0037 | 0.1018 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1018 | 1 |
Loa Loa (eye worm) | LGC-31 protein | 0.0037 | 0.1018 | 1 |
Onchocerca volvulus | 0.0037 | 0.1018 | 1 | |
Brugia malayi | Cation transporter family protein | 0.0037 | 0.1018 | 1 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0037 | 0.1018 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0037 | 0.1018 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0037 | 0.1018 | 1 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0037 | 0.1018 | 1 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0037 | 0.1018 | 1 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0037 | 0.1018 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0037 | 0.1018 | 1 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0037 | 0.1018 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0188 | 1 | 0.5 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0188 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1018 | 1 |
Onchocerca volvulus | 0.0037 | 0.1018 | 1 | |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0037 | 0.1018 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0037 | 0.1018 | 1 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0037 | 0.1018 | 1 |
Onchocerca volvulus | Putative nachr subunit | 0.0037 | 0.1018 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0037 | 0.1018 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1018 | 1 |
Brugia malayi | Cation transporter family protein | 0.0037 | 0.1018 | 1 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0037 | 0.1018 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0037 | 0.1018 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1018 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0037 | 0.1018 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0037 | 0.1018 | 1 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0037 | 0.1018 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CL (ADMET) | = 0.015 microL/min/mg | Intrinsic clearance in mouse liver microsomes after 15 mins by LC/MS/MS analysis | ChEMBL. | 23181587 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.