Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | 4,9-DHSA hydrolase | 0.1325 | 0.995 | 1 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0418 | 0.3047 | 0.5 |
Onchocerca volvulus | 0.0418 | 0.3047 | 0.5 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0418 | 0.3047 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0418 | 0.3047 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0418 | 0.3047 | 0.5 |
Loa Loa (eye worm) | lipase | 0.0418 | 0.3047 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.0418 | 0.3047 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0418 | 0.3047 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.0418 | 0.3047 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0418 | 0.3047 | 0.5 |
Brugia malayi | Lipase family protein | 0.0418 | 0.3047 | 0.5 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0418 | 0.3047 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 4 uM | In vitro inhibition of human recombinant IL-1beta-induced breakdown of bovine cartilage in a cartilage organ culture assay | ChEMBL. | 7932530 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.