Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | fused N-acetyl glucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyl transferase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | Get druggable targets OG5_131193 | All targets in OG5_131193 |
Mycobacterium leprae | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | Get druggable targets OG5_131193 | All targets in OG5_131193 |
Mycobacterium ulcerans | bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase | Get druggable targets OG5_131193 | All targets in OG5_131193 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | Get druggable targets OG5_131193 | All targets in OG5_131193 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.1401 | 1 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | 0.0684 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.1401 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0138 | 0.1401 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0138 | 0.1401 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0138 | 0.1401 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.1829 | 1 |
Toxoplasma gondii | eukaryotic initiation factor-2B, gamma subunit, putative | 0.0125 | 0.1211 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0138 | 0.1401 | 1 |
Treponema pallidum | licC protein (licC) | 0.0125 | 0.1211 | 0.5 |
Echinococcus multilocularis | geminin | 0.0165 | 0.1829 | 1 |
Echinococcus granulosus | geminin | 0.0165 | 0.1829 | 1 |
Mycobacterium ulcerans | bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase | 0.0684 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.0684 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.1829 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7.046 | Inhibition of Escherichia coli GlmU acetyltransferase activity assessed as coenzyme A production using acetyl CoA substrate | ChEMBL. | 25544688 |
IC50 (binding) | = 0.09 uM | Inhibition of Escherichia coli GlmU acetyltransferase activity assessed as coenzyme A production using acetyl CoA substrate | ChEMBL. | 25544688 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.