Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Sus scrofa | Aminopeptidase N | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | aminopeptidase N | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Schistosoma japonicum | ko:K01256 membrane alanyl aminopeptidase [EC3.4.11.2], putative | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Onchocerca volvulus | Get druggable targets OG5_127217 | All targets in OG5_127217 | |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Loa Loa (eye worm) | peptidase family M1 containing protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Echinococcus multilocularis | aminopeptidase N | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Brugia malayi | Peptidase family M1 containing protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Aminopeptidase N | 963 aa | 893 aa | 32.0 % | |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 981 aa | 29.2 % |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 988 aa | 28.5 % |
Echinococcus granulosus | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 975 aa | 29.1 % |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 981 aa | 28.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0902 | 0.1526 |
Echinococcus multilocularis | geminin | 0.0188 | 1 | 1 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0042 | 0 | 0.5 |
Entamoeba histolytica | aminopeptidase, putative | 0.0042 | 0 | 0.5 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0042 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0188 | 1 | 1 |
Brugia malayi | Peptidase family M1 containing protein | 0.0143 | 0.6928 | 1 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0042 | 0 | 0.5 |
Echinococcus multilocularis | aminopeptidase N | 0.0143 | 0.6928 | 0.6928 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0042 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0042 | 0 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0042 | 0 | 0.5 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0042 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.0902 | 0.1302 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.0902 | 0.1526 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0042 | 0 | 0.5 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0116 | 0.5054 | 0.8549 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.4038 | 0.683 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.0902 | 0.1302 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0042 | 0 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0042 | 0 | 0.5 |
Echinococcus granulosus | aminopeptidase N | 0.0143 | 0.6928 | 0.6928 |
Onchocerca volvulus | 0.0143 | 0.6928 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0188 | 1 | 1 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0042 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.5912 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.1 uM | Inhibition of APN in porcine kidney microsome assessed as inhibition of L-Leu-p-nitroanilide substrate hydrolysis incubated for 5 mins before substrate addition by UV-Vis spectrophotometric analysis | ChEMBL. | 24900417 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.